The small nucleotides pppGpp and ppGpp (or (p)ppGpp) are rapidly synthesized in response
to nutritional stress. In Escherichia coli, the enzymes RelA and SpoT are triggered by …

Background Chronic subdural hematoma is a very common neurosurgical condition. Although
conventional surgical methods, such as burr hole irrigation, have been the mainstay of …

Extracellular vesicles (EV), including exosomes and microvesicles, are nano-sized intercellular
communication vehicles that participate in a multitude of physiological processes. Due to …

This review article briefly describes: (a) the advantages in developing multifunctional
nanoparticles for cancer-imaging and therapy, (b) the advantages and limitations of most of the …

Whole-genome sequencing is a powerful technique for obtaining the reference sequence
information of multiple organisms. Its use can be dramatically expanded to rapidly identify …

In many bacteria, there is a genome-wide bias towards co-orientation of replication and
transcription, with essential and/or highly-expressed genes further enriched co-directionally. We …

Actively dividing cells perform robust and accurate DNA replication during fluctuating nutrient
availability, yet factors that prevent disruption of replication remain largely unknown. Here …

Functionalized quantum dots (QDs) have been widely explored for multimodality bioimaging
and proven to be versatile agents. Attaching positron-emitting radioisotopes onto QDs not …

We have demonstrated that gold nanocage-photosensitizer conjugates can enable dual
image-guided delivery of photosensitizer and significantly improve the efficacy of photodynamic …

In eukaryotes, it is unknown whether mismatch repair (MMR) is temporally coupled to DNA
replication and how strand-specific MMR is directed. We fused Saccharomyces cerevisiae …