Physical activity is essential to maintain skeletal mass and structure, but its effect seems to
diminish with age. To test the hypothesis that bone becomes less sensitive to mechanical …

Bone loss occurs during adulthood in both women and men and affects trabecular bone more
than cortical bone. The mechanism responsible for trabecular bone loss during adulthood …

Bone is a tissue with enormous adaptive capacity, balancing resorption and formation processes.
It is known that mechanical loading shifts this balance towards an increased formation, …

Mechanical loading can increase cortical bone mass by shifting the balance between bone
formation and resorption towards increased formation. With advancing age resorption …

Dynamic processes modify bone micro-structure to adapt to external loading and avoid
mechanical failure. Age-related cortical bone loss is thought to occur because of increased …

Bone adapts to changes in the local mechanical environment (eg strains) through formation
and resorption processes. However, the bone adaptation response is significantly reduced …

Bone undergoes continual damage repair and structural adaptation to changing external loads
with the aim of maintaining skeletal integrity throughout life. The ability to monitor bone (re…

Bone adaptation optimizes mass and structure, but the mechano-response is already
reduced at maturation. Downregulation of sclerostin was believed to be a mandatory step in …

Bone has an adaptive capacity to maintain structural integrity. However, there seems to be a
heterogeneous cortical (re)modeling response to loading at different regions within the …

A new therapeutic option to treat osteoporosis is focused on Wnt signaling and its inhibitor
sclerostin, a product of the Sost gene. In this work, we study the effect of sclerostin deficiency …