Diffuse glioma growth: a guerilla war
A Claes, AJ Idema, P Wesseling - Acta neuropathologica, 2007 - Springer
In contrast to almost all other brain tumors, diffuse gliomas infiltrate extensively in the neuropil.
This growth pattern is a major factor in therapeutic failure. Diffuse infiltrative glioma cells …
This growth pattern is a major factor in therapeutic failure. Diffuse infiltrative glioma cells …
Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors
JFM Jacobs, AJ Idema, KF Bol, S Nierkens… - Neuro …, 2009 - academic.oup.com
The brain is a specialized immune site representing a unique tumor microenvironment. The
availability of fresh brain tumor material for ex vivo analysis is often limited because large …
availability of fresh brain tumor material for ex vivo analysis is often limited because large …
Prognostic significance and mechanism of Treg infiltration in human brain tumors
JFM Jacobs, AJ Idema, KF Bol, JA Grotenhuis… - Journal of …, 2010 - Elsevier
Regulatory T cells (Tregs) accumulate in tumors and can contribute to the dismal immune
responses observed in these tumors. We reported that the percentage of tumor infiltrating …
responses observed in these tumors. We reported that the percentage of tumor infiltrating …
[HTML][HTML] Significance of complete 1p/19q co-deletion, IDH1 mutation and MGMT promoter methylation in gliomas: use with caution
…, A Sijben, J Rijntjes, BBJ Tops, AJ Idema… - Modern Pathology, 2013 - Elsevier
The histopathological diagnosis of diffuse gliomas often lacks the precision that is needed
for tailored treatment of individual patients. Assessment of the molecular aberrations will …
for tailored treatment of individual patients. Assessment of the molecular aberrations will …
Discrimination between metastasis and glioblastoma multiforme based on morphometric analysis of MR images
…, PWT Krooshof, GJ Postma, AJ Idema… - American journal …, 2011 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Solitary MET and GBM are difficult to distinguish by using
MR imaging. Differentiation is useful before any metastatic work-up or biopsy. Our …
MR imaging. Differentiation is useful before any metastatic work-up or biopsy. Our …
Nosologic imaging of the brain: segmentation and classification using MRI and MRSI
J Luts, T Laudadio, AJ Idema… - NMR in Biomedicine …, 2009 - Wiley Online Library
A new technique is presented to create nosologic images of the brain based on magnetic
resonance imaging (MRI) and magnetic resonance spectroscopic imaging (MRSI). A nosologic …
resonance imaging (MRI) and magnetic resonance spectroscopic imaging (MRSI). A nosologic …
[HTML][HTML] On the relevance of automatically selected single-voxel MRS and multimodal MRI and MRSI features for brain tumour differentiation
GJ Postma, J Luts, AJ Idema, M Julià-Sapé… - Computers in Biology …, 2011 - Elsevier
In order to evaluate the relevance of magnetic resonance (MR) features selected by
automatic feature selection techniques to build classifiers for differential diagnosis and tissue …
automatic feature selection techniques to build classifiers for differential diagnosis and tissue …
3′-Deoxy-3′-18F-Fluorothymidine PET–Derived proliferative volume predicts overall survival in high-grade glioma patients
AJS Idema, AL Hoffmann, HD Boogaarts… - Journal of Nuclear …, 2012 - Soc Nuclear Med
3′-deoxy-3′- 18 F-fluorothymidine ( 18 F-FLT) is a radiopharmaceutical depicting tumor
cell proliferation with PET. In malignancies of the lung, breast, head and neck, digestive tract, …
cell proliferation with PET. In malignancies of the lung, breast, head and neck, digestive tract, …
Multi-class glioma segmentation on real-world data with missing MRI sequences: Comparison of three deep learning algorithms
…, WA Van den Brink, J Furtner, SJ Han, AJS Idema… - Scientific reports, 2023 - nature.com
This study tests the generalisability of three Brain Tumor Segmentation (BraTS) challenge
models using a multi-center dataset of varying image quality and incomplete MRI datasets. In …
models using a multi-center dataset of varying image quality and incomplete MRI datasets. In …
Preoperative brain tumor imaging: Models and software for segmentation and standardized reporting
…, J Furtner, S Hervey-Jumper, AJS Idema… - Frontiers in …, 2022 - frontiersin.org
For patients suffering from brain tumor, prognosis estimation and treatment decisions are
made by a multidisciplinary team based on a set of preoperative MR scans. Currently, the lack …
made by a multidisciplinary team based on a set of preoperative MR scans. Currently, the lack …