Major advances in understanding the cellular mechanisms of brain injury have presented a
host of potential targets for intervention. This is particularly true of hypoxic-ischemic injury, …

The central autonomic nervous system (ANS) is essential for maintaining cardiovascular and
respiratory homeostasis in the newborn and has a critical role in supporting higher cortical …

Near-infrared spectroscopy (NIRS) was introduced in 1977 as a technology that is capable
of noninvasive monitoring of oxygenation in living tissue [1]. NIRS operates on the principle …

… A formal neurologic examination was performed by a pediatric neurologist (Dr du Plessis
or Dr Bassan), which included assessment of cranial size, cranial nerves, special senses, and …

Background— Adverse neurodevelopmental outcome is an important source of morbidity in
children with congenital heart disease (CHD). A significant proportion of newborns with …

OBJECTIVE. The survival of very low birth weight infants has increased markedly in recent
years. Unfortunately, the prevalence of significant and lifelong motor, cognitive, and …

OBJECTIVES. The objectives of this study were to delineate the etiologic profile and
neurodevelopmental outcome of neonatal seizures in the current era of neonatal intensive care and …

Objective. Cognitive impairments and academic failure are commonly reported in survivors
of preterm birth. Recent studies suggest an important role for the cerebellum in the …

… Available cranial US studies performed for clinical indications during the first 5 d (ie the
hemodynamic study period) were interpreted by two investigators (DND and AJdu P.) blinded to …

BACKGROUND: We hypothesized that cognitive impairment and hemodynamic instability
after infant cardiac surgery with cardiopulmonary bypass might be exacerbated by …