Objective To determine the contemporary etiology, burden, and short-term outcomes of
seizures in neonates monitored with continuous video-electroencephalogram (cEEG). Study …

Objective To evaluate the role of copy number abnormalities detectable using chromosomal
microarray (CMA) testing in patients with epilepsy at a tertiary care center. Methods We …

Background Factors determining the extension and degree of inflammation in the colonic
mucosa of patients with ulcerative colitis (UC) are largely unknown, but CD4 + CD25 high …

Objective We sought to identify genetic causes of early onset epileptic encephalopathies
with burst suppression (Ohtahara syndrome and early myoclonic encephalopathy) and …

Objective In the absence of controlled trials, treatment of neonatal seizures has changed
minimally despite poor drug efficacy. We tested bumetanide added to phenobarbital to treat …

Severe paediatric epilepsies such as CDKL5 Deficiency Disorder (CDD) are extremely
debilitating, largely due to the early-onset and refractory nature of the seizures. Existing treatment …

Importance Genomic advances inform our understanding of epilepsy and can be translated
to patients as precision diagnoses that influence clinical treatment, prognosis, and …

This study compares a reduced electrode montage (9 electrodes) with the full 10/20 electrode
montage for the ability to detect and characterize neonatal seizures and background …

Objective Pathogenic variants involving the CDKL 5 gene result in a severe epileptic
encephalopathy, often later presenting with features similar to Rett syndrome. Cardinal features of …

By definition, unprovoked seizures are not precipitated by an identifiable factor, such as fever
or trauma. A thorough history and physical examination are essential to caring for pediatric …