Obesity is now reaching epidemic proportions in both developed and developing countries
and is affecting not only adults but also children and adolescents. Over the last 20 years, …

A growing amount of evidence suggests that regional fat distribution plays an important part
in the development of an unfavorable metabolic and cardiovascular risk profile. Epicardial …

Background Obesity has been recognised as an important contributing factor in the development
of various diseases, but comparative data on this condition are limited. We therefore …

Background Obesity is a major risk factor for cardiovascular disease, but the most predictive
measure for different ethnic populations is not clear. We aimed to assess whether markers of …

Background The long-term effects of sibutramine treatment on the rates of cardiovascular
events and cardiovascular death among subjects at high cardiovascular risk have not been …

Hypertension is a common disorder of multifactorial origin that constitutes a major risk factor
for cardiovascular events such as stroke and myocardial infarction. Previous studies …

Obesity is the main risk factor for the development of type 2 diabetes. Activation of the central
endocannabinoid system increases food intake and promotes weight gain. Blockade of the …

Prion-like propagation of tau aggregation might underlie the stereotyped progression of
neurodegenerative tauopathies. True prions stably maintain unique conformations ("strains") in …

… Arya Sharma reports receiving speaker’s bureau and consulting fees from Novo Nordisk,
Bausch Pharmaceuticals and Astra-Zeneca. Laurent Biertho reports receiving grants from …

The renin-angiotensin-aldosterone system has been causally implicated in obesity-associated
hypertension. We studied the influence of obesity and weight reduction on the circulating …