Molecular features assisting in diagnosis, surgery, and treatment decision making in low-grade gliomas
…, AL Cohen, RL Jensen, KL Salzman, AP Prescot… - Neurosurgical …, 2015 - thejns.org
… This theory is supported by studies of serial biopsy samples obtained in patients with
glioma, in which the IDH1 mutation appears to be a relatively early genetic event,11,13,37 …
glioma, in which the IDH1 mutation appears to be a relatively early genetic event,11,13,37 …
Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania
BACKGROUND: At excitatory synapses, glutamate released from neurons is taken up by
glial cells and converted to glutamine, which is cycled back to neurons. Alterations in this …
glial cells and converted to glutamine, which is cycled back to neurons. Alterations in this …
[HTML][HTML] Hippocampal GABA enables inhibitory control over unwanted thoughts
…, MM Correia, CS Ferreira, AP Prescot… - Nature …, 2017 - nature.com
… 2D J-resolved 1 H MRS data were acquired for three brain ROIs using the sequence and
methodology previously described in Prescot and Renshaw 57 . The imaging parameters were …
methodology previously described in Prescot and Renshaw 57 . The imaging parameters were …
Creatine abnormalities in schizophrenia and bipolar disorder
Total creatine (Cr) levels are widely used as an internal reference for the quantification of
other metabolites in 1 H magnetic resonance spectroscopy (MRS). However, Cr plays an …
other metabolites in 1 H magnetic resonance spectroscopy (MRS). However, Cr plays an …
Elevated gamma-aminobutyric acid levels in chronic schizophrenia
BACKGROUND: Despite widely replicated abnormalities of gamma-aminobutyric acid (GABA)
neurons in schizophrenia postmortem, few studies have measured tissue GABA levels in …
neurons in schizophrenia postmortem, few studies have measured tissue GABA levels in …
[HTML][HTML] Rapid enhancement of glutamatergic neurotransmission in bipolar depression following treatment with riluzole
…, J McCarthy, JL Roberts, AP Prescot… - …, 2010 - nature.com
Glutamatergic abnormalities may underlie bipolar disorder (BD). The glutamate-modulating
drug riluzole may be efficacious in bipolar depression, but few in vivo studies have …
drug riluzole may be efficacious in bipolar depression, but few in vivo studies have …
Neurochemical alterations in adolescent chronic marijuana smokers: a proton MRS study
AP Prescot, AE Locatelli, PF Renshaw… - Neuroimage, 2011 - Elsevier
Converging evidence from neuroimaging and neuropsychological studies indicates that heavy
marijuana use is associated with cingulate dysfunction. However, there has been limited …
marijuana use is associated with cingulate dysfunction. However, there has been limited …
Brain gamma‐aminobutyric acid (GABA) abnormalities in bipolar disorder
RO Brady Jr, JM McCarthy, AP Prescot… - Bipolar …, 2013 - Wiley Online Library
Objectives Gamma‐aminobutyric acid ( GABA ) abnormalities have been implicated in bipolar
disorder. However, due to discrepant studies measuring postmortem, cerebrospinal fluid, …
disorder. However, due to discrepant studies measuring postmortem, cerebrospinal fluid, …
γ-Amino butyric acid and glutamate abnormalities in adolescent chronic marijuana smokers
AP Prescot, PF Renshaw, DA Yurgelun-Todd - Drug and alcohol …, 2013 - Elsevier
BACKGROUND: An increasing body of evidence from neuropsychological and neuroimaging
studies suggests that exposure to marijuana throughout adolescence disrupts key cortical …
studies suggests that exposure to marijuana throughout adolescence disrupts key cortical …
T2 relaxation time abnormalities in bipolar disorder and schizophrenia
There are substantial abnormalities in the number, density, and size of cortical neurons and
glial cells in bipolar disorder and schizophrenia. Because molecule‐microenvironment …
glial cells in bipolar disorder and schizophrenia. Because molecule‐microenvironment …