Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs
used daily in oncology include clinical TNM stage, objective response and left ventricular …

Tumours require a vascular supply to grow and can achieve this via the expression of pro-angiogenic
growth factors, including members of the vascular endothelial growth factor (VEGF…

All solid tumours require a vascular supply in order to progress. Although the ability to
induce angiogenesis (new blood vessel growth) has long been regarded as essential to this …

Inhibitors of α v β 3 and α v β 5 integrin have entered clinical trials as antiangiogenic agents
for cancer treatment but generally have been unsuccessful. Here we present in vivo …

Evidence for a new signaling mechanism consisting of ligand-independent lateral
propagation of receptor activation in the plasma membrane is presented. We visualized the …

… ; and an absent response (AR) if the lesion either did not change group or went from group-2
to group-3 after treatment. Lesions scored as AR were considered to be poor responders, …

Identifying genetic biomarkers of synthetic lethal drug sensitivity effects provides one approach
to the development of targeted cancer therapies. Mutations in ARID1A represent one of …

Objective— The role of the nuclear receptor peroxisome-proliferator activated receptor (PPAR)-β/δ
in endothelial cells remains unclear. Interestingly, the selective PPARβ/δ ligand …

The epidermal growth factor receptor (EGFR) belongs to the receptor tyrosine kinase (RTK)
superfamily and is involved in regulating cell proliferation, differentiation and motility 1 . …

The liver is host to many metastatic cancers, particularly colorectal cancer, for which the last
2 decades have seen major advances in diagnosis and treatment. The liver is a vital organ, …