Non-invasive approaches for cell-free DNA (cfDNA) assessment provide an opportunity for
cancer detection and intervention. Here, we use a machine learning model for detecting tumor…

Computational fluid dynamics (CFD) simulations of airflow and particle deposition in geometries
representing the human tracheobronchial tree were conducted. Two geometries were …

Conjugation of ligands to nano-scale drug carriers targeting over-expressed cell surface
receptors is a promising approach for delivery of therapeutic agents to tumor cells. However, …

… AV Annapragada reports a patent for detecting liver cancer using cfDNA fragmentation
pending. DC Bruhm reports a patent for 63/423,003 pending, a patent for 63/290,017 pending …

Somatic mutations are a hallmark of tumorigenesis and may be useful for non-invasive
diagnosis of cancer. We analyzed whole-genome sequencing data from 2,511 individuals in the …

Long-circulating nanocarriers have been extensively studied to deliver chemotherapeutics;
however, the inclusion of targeting agents compromises circulation times thereby offsetting …

Abnormalities in the cerebrovascular system play a central role in many neurologic diseases.
The on-going expansion of rodent models of human cerebrovascular diseases and the …

The binding of folate-targeted drug carriers to a receptor-bearing cell surface is modeled
using a deterministic approach. The model accounts for the presence of multiple folate ligands …

RATIONALE AND OBJECTIVES: Although soluble nonionic iodine compounds with low
systemic toxic effects have been developed for use in computed tomography (CT), they have …

Purpose: To prospectively predict the effectiveness of a clinically used nanochemotherapeutic
agent by detecting and measuring the intratumoral uptake of an x-ray contrast agent …