Cerebrospinal fluid (CSF) concentrations are used as a surrogate measure of central nervous
system (CNS) availability of drugs. Systemically administered drugs can reach CSF either …

Context The amygdala is associated with socioemotional function and has been implicated
in the pathophysiology of autism. Objective To examine the relationship between amygdalar …

Background Carbon dioxide absorbents degrade sevoflurane, particularly at low gas flow
rates, to fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A). Compound A …

IMPLICATIONS: We performed a retrospective chart review of awake craniotomies for
epilepsy at a single, large-volume center and examined the incidence of complications when …

Context The brain pathophysiological abnormalities underlying autism remain unclear.
Neuroimaging and histological studies suggest cellular abnormalities early in the course of the …

This study assessed midsagittal corpus callosum cross sectional areas in 3–4 year olds with
autism spectrum disorder (ASD) compared to typically developing (TD) and …

Sevoflurane degradation by carbon dioxide absorbents during low-flow anesthesia forms
the haloalkene Compound A, which causes nephrotoxicity in rats. Numerous studies have …

Background Sevoflurane is degraded to compound A (CpA) by carbon dioxide absorbents
containing strong base. CpA is nephrotoxic in rats. Patient exposure to CpA is increased with …

This study examined the concentration-related effects of sevoflurane and isoflurane on
cerebral physiology and plasma inorganic fluoride concentrations. Middle cerebral artery flow …

Background Sevoflurane is metabolized to free fluoride and hexafluoroisopropanol (HFIP).
Cytochrome P450 2E1 is the major isoform responsible for sevoflurane metabolism by …