The development of noninvasive methods to detect and monitor tumors continues to be a
major challenge in oncology. We used digital polymerase chain reaction–based technologies …

Autoimmune (lymphocytic) hypophysitis is a rare disease that should be considered in the
differential diagnosis of any nonsecreting pituitary mass, especially when occurring during …

Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify
the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined …

Introduction Surgery is first-line therapy for glioblastoma, and there is evidence that gross
total resection is associated with improved survival. Gross total resection, however, is not …

Transformed, oncogenic precursors, possessing both defining neural-stem-cell properties
and the ability to initiate intracerebral tumours, have been identified in human brain cancers 1 …

Object With recent advances in the adjuvant treatment of malignant brain astrocytomas, it is
increasingly debated whether extent of resection affects survival. In this study, the authors …

Brain tumors can arise following deregulation of signaling pathways normally activated
during brain development and may derive from neural stem cells. Given the requirement for …

OBJECTIVE: It remains unknown whether the extent of surgical resection affects survival or
disease progression in patients with supratentorial low-grade gliomas. METHODS: We …

Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific
biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually …

Purpose: Checkpoint molecules like programmed death-1 (PD-1) and T-cell immunoglobulin
mucin-3 (TIM-3) are negative immune regulators that may be upregulated in the setting of …