The nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder
characterized by multiple basal cell carcinomas (BCCs), pits of the palms and soles, jaw …

The p16 gene is located in chromosome 9p21, a region that is linked to familial melanoma
and homozygously deleted in many tumour cell lines. We describe eight p16 germline …

Nevoid basal cell carcinoma syndrome (NBCC; Gorlin syndrome), an autosomal dominant
disorder linked to 9q22.3–q31, and caused by mutations in PTC, the human homologue of the …

Background: Chordoma, a rare tumor arising from notochordal remnants, has been described
to date only by single-institution case series or small population-based surveys. Methods: …

Protein complexes consisting of a cyclin-dependent kinase (CDK4 or CDK6) and cyclin D
control passage through the G1 checkpoint of the cell cycle by phosphorylating the …

The sonic hedgehog (SHH) signaling pathway directs the embryonic development of diverse
organisms and is disrupted in a variety of malignancies. Pathway activation is triggered by …

Background A gene on chromosome 9p, p16INK4, has been implicated in the pathogenesis
of cutaneous malignant melanoma in 19 melanoma-prone families. In 10 of these kindreds …

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide
association studies, we observed large chromosomal abnormalities in a subset of clones in …

Objective To examine incidence and survival patterns of acral lentiginous melanoma (ALM)
in the United States. Design Population-based registry study. We used the Surveillance, …

Background: Germline mutations in the CDKN2A gene, which encodes two proteins (p16INK4A
and p14ARF), are the most common cause of inherited susceptibility to melanoma. We …