… B. Van Overmeire wishes to thank all collaborators, parents and infants that participated in
the clinical trials supporting this review. S. Chemtob is recipient of a Canada Research Chair. …

Ibuprofen (IBU) has previously been shown to be as effective as indomethacin (INDO) in
closing the patent ductus arteriosus (PDA) of preterm infants, without severely affecting renal …

Oxygen is a neonatal health hazard that should be avoided in clinical practice. In this review,
an international team of neonatologists and nurses assessed oxygen saturation ( S p O 2 ) …

Background Indomethacin is the conventional treatment for patent ductus arteriosus in preterm
infants. However, its use is associated with various side effects. In a prospective study, we …

Background Cyclooxygenase inhibitors are commonly used in infants with patent ductus
arteriosus (PDA), but the benefit of these drugs is uncertain. Methods In this multicenter, …

… overlay panel Bart Van Overmeire MD, PhD , Hilde Van de Broek MD , Paul Van Laer MD ,
… B Van Overmeire, F Brus, KJ Van Acker, JC Van der Auwera, M Schasfoort, NJ Elzenga, et al…

Background In animal models, inhaled nitric oxide improved gas exchange and lung structural
development, but its use in premature infants at risk of developing bronchopulmonary …

Background Neonates who are in pain or are stressed during care in the intensive care unit (ICU)
are often given sedation or analgesia. We investigated the current use of sedation or …

There is a need to ensure standardization of training and clinical practice guidelines, with
quality assurance systems in place to maintain safe dissemination of this practice. There are …

AIM To evaluate the efficiency and side effects of ibuprofen for the early treatment of patent
ductus arteriosus (PDA)and compare it with indomethacin. METHODS Forty preterm infants …