BACKGROUND AND PURPOSE: The complex MR imaging appearance of glioblastoma is
a function of underlying histopathologic heterogeneity. A better understanding of these …

Background Topotecan is cytotoxic to glioma cells but is clinically ineffective because of drug
delivery limitations. Systemic delivery is limited by toxicity and insufficient brain penetrance, …

Purpose: While MGMT promoter methylation (mMGMT) is predictive of response to alkylating
chemotherapy and guides treatment decisions in glioblastoma, its role in grade 2 and 3 …

Tuberous sclerosis complex (TSC) is a developmental disorder associated with epilepsy,
autism, and cognitive impairment. Despite inactivating mutations in the TSC1 or TSC2 genes …

BACKGROUND Accurate tissue sampling in nonenhancing (NE) gliomas is a unique surgical
challenge due to their intratumoral histological heterogeneity and absence of contrast …

Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain
cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell …

BACKGROUND AND PURPOSE: Malignant glioma is a highly infiltrative malignancy that
causes variable disruptions to the structure and function of the cerebrovasculature. While many …

While several studies have attributed the development of tumour-associated seizures to an
excitatory-inhibitory imbalance, we have yet to resolve the spatiotemporal interplay between …

The purpose of this study is to develop a platform in which the cellular and molecular
underpinnings of chronic focal neocortical lesional epilepsy can be explored and use it to …

Gliomas are highly aggressive brain tumors characterized by poor prognosis and composed
of diffusely infiltrating tumor cells that intermingle with non-neoplastic cells in the tumor …