Cognitive decline associated with old age and consistent with the diagnosis of primary
degenerative dementia is a unique clinical syndrome with characteristic phenomena and …

Background Overstimulation of the N-methyl-D-aspartate (NMDA) receptor by glutamate is
implicated in neurodegenerative disorders. Accordingly, we investigated memantine, an …

There is increasing evidence that subjective cognitive decline (SCD) in individuals with
unimpaired performance on cognitive tests may represent the first symptomatic manifestation of …

The Functional Assessment Staging of Dementia (FAST) is a 16-item scale, more detailed
version of, the 7-point functioning and self-care axis (Axis V) of the Brief Cognitive Rating …

Before the development of the Behavioral Pathology in Alzheimer's Disease (BEHAVE-AD)
rating scale in 1987 by Reisberg and colleagues and its predecessor scale, the Symptoms of …

At the present time, there is increasing recognition and understanding of the mild cognitive
impairment (MCI) entity as a stage which is a frequent precursor and harbinger of …

… Reisberg and associates disagree with respect to the GDS 3 stage, which they believe to
be … Reisberg points out that the global staging definition of mild cognitive impairment has …

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

Cerebrovascular disease is the second most common cause of acquired cognitive impairment
and dementia and contributes to cognitive decline in the neurodegenerative dementias. …

Limited information is available regarding the incidence, nature, and treatment of behavioral
problems in Alzheimer's disease (AD). A chart review of 57 outpatients with a diagnosis of …