The cellular mechanisms underlying functional hyperemia—the coupling of neuronal
activation to cerebral blood vessel responses—are not yet known. Here we show in rat cortical …

BACKGROUND AND PURPOSE: Because cerebral perfusion imaging for acute stroke is
unavailable in most hospitals, we investigated the feasibility of a method of perfusion scanning …

Background The vascular contributions to neurodegeneration and neuroinflammation may
be assessed by magnetic resonance imaging (MRI) and ultrasonography (US). This review …

Background: During sepsis progression microcirculatory dysfunction precedes
macrocirculatory failure, partly explaining the occurrence of early organ dysfunction. The matter …

Background Alzheimer's disease (AD) leads to a degeneration of the nucleus basalis of
Meynert and thus to decreased cholinergic tonus in the brain. The transcription of endothelial …

Background Adequate cerebral blood flow (CBF) is mainly governed by neurovascular coupling
(NC) which adapts local CBF to underlying cortical activity, and cerebral autoregulation (…

Objective To determine whether a history of cerebrovascular disease (CVD) increases risk of
severe coronavirus disease 2019 (COVID-19). Methods In a retrospective multicenter study…

Objective Autonomic failure (AF) affects the peripheral vascular system, but little is known
about its influence on cerebrovascular regulation. Patients with familial amyloidotic …

Background Stimulation of the vagus nerve has modulating, anti-inflammatory effects on the
cellular immune response in the blood and the spleen, stabilizing brain function. Here, we …

Dualistic effects of acetylcholine-esterase inhibitors on neuronal as well as vasoregulative
function have been debated. This study investigated for the first time effects of medication on …