Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

The development of probes for single-molecule imaging has dramatically facilitated the study
of individual molecules in cells and other complex environments. Single-molecule probes …

Purpose: Medulloblastoma is the most common malignant brain tumor of childhood. After
treatment with surgery and radiation therapy, approximately 60% of children with …

Background: Youths with bipolar disorder are ideal for studying illness pathophysiology
given their early presentation, lack of extended treatment, and high genetic loading. Adult …

✓ It has previously been reported in a single-institution trial that progression-free survival of
children with medulloblastoma treated with radiotherapy and 1-(2-chloroethyl)-3-cyclohexyl-1…

OBJECTIVE: Psychotic affective disorders are the most prevalent idiopathic psychoses, but
their outcome from onset has rarely been studied. In this study, the authors determined the …

Imaging at the single-molecule level reveals heterogeneities that are lost in ensemble imaging
experiments, but an ongoing challenge is the development of luminescent probes with …

• To test the validity of theDSM-IIIdiagnosis of borderline personality disorder (BPD), we
examined the phenomenology, family history, treatment response, and four-to-seven-year long-…

Purpose: The purpose of this statement is to review the literature regarding mitochondrial
disease and to provide recommendations for optimal diagnosis and treatment. This statement …

• The clinical use of antipsychotic agents may be enhanced by considering their dose-effect
characteristics. In particular, assessment of immediate and later follow-up treatment of …