PURPOSE To determine if tumor-specific monoclonal antibodies conjugated to superparamagnetic
monocrystalline iron oxide nanoparticles can be used to yield specific diagnoses …

DELIVERY OF VIRAL particles to the brain is limited by the volume of distribution that can be
obtained. Additionally, there is currently no way to non-invasively monitor the distribution of …

Increasing the delivery of therapeutic drugs to the brain improves outcome for patients with
brain tumors. Osmotic opening of the blood-brain barrier (BBB) can markedly increase drug …

Osmotic blood-brain barrier disruption with intraarterial chemotherapy has been shown to be
beneficial in the treatment of malignant brain tumors. Imaging blood-brain barrier disruption …

When carboplatin (cis-diammine-1,1-cyclobutane-dicarboxylato-platinum) delivery to brain
tumors is optimized with osmotic blood-brain barrier disruption (BBBD), high frequency …

… P., and McCormick, CI Growth of human lung tumor in the brain of the nude rat as a model
to evaluate antitumor agent delivery across the blood-brain barrier. Cancer Res., 45: 2827-…

We have developed a brain tumor model in the nude rat utilizing NCI-N417D human small
cell carcinoma of the lung grown both intracerebrally and sc The median latency period from …

: In the dog, osmotic opening of the blood-brain barrier (BBB) in the posterior circulation via
the vertebral artery and in the anterior circulation via the internal carotid artery was utilized to …

… MCCORMICK Department of Neurosurgery, Oregon Health Sciences Uniuersity, … MCCORMICK.
OSmotic blood-brain barrier opening to IgM monoclonal antibody in … CI MCCORMICK, …

To assess how to maximize drug delivery to intracerebral tumors and surrounding brain, this
study examined the effects of route and method of administration and tumor size on the …