Astrocytic tumors account for 42% of childhood brain tumors, arising in all anatomical regions
and associated with neurofibromatosis type 1 (NF1) in 15%. Anatomical site determines …

Cytotoxic CD4 Th1 cells are emerging as a therapeutically useful T cell lineage that can
effectively target tumors, but until now the pathways that govern their differentiation have been …

Discussion Neurocutaneous melanosis is an embryonal neuroectodermal dysplasia.
Primarily infants and young children are affected, and no sex predilection is known. The usual …

CD134-and CD137-primed CD8 T cells mount powerful effector responses upon recall, but
even without recall these dual-costimulated T cells respond to signal 3 cytokines such as IL-…

T‐cell tolerance to tumor antigens represents a major hurdle in generating tumor immunity.
Combined administration of agonistic monoclonal antibodies (mAbs) to the costimulatory …

… Although it is clear that coadministration of poly(I:C) with antigen elicits strong adjuvant
effects in mice, we found that poly(I:C) injection before antigen substantially reduced antigen-…

… CD4 T cell response to DCo in BALB/c mice that are Th2 predisposed (44). Thy1.1 + BALB/…
BALB/c mice were inoculated with A20HA (C and D) or parental A20WT (E and F) lymphoma …

… Scatter plots show the percentage of specific TEa CD4 T cells that express Eomes (A) and
Runx3 (B) and the total number of specific CD4 T cells (C). (D–F) A second experiment was …

Secondary tumours of small intestine account for 10% of all small bowel cancers. The most
common sites of primary tumour metastasizing to small bowel are uterus, cervix, colon, lung, …

… The initial oven temperature of 70C was maintained for 5 min and then raised to 300C at
3.5C/min. MS data were processed using the Agilent GC/MS software under both scan and SIM …