Physical factors effecting cerebral aneurysm pathophysiology

C Sadasivan, DJ Fiorella, HH Woo… - Annals of biomedical …, 2013 - Springer
Many factors that are either blood-, wall-, or hemodynamics-borne have been associated
with the initiation, growth, and rupture of intracranial aneurysms. The distribution of cerebral …

Anti‐Inflammatory Property of n‐Hexadecanoic Acid: Structural Evidence and Kinetic Assessment

…, PK Mandal, P Karthe, C Sadasivan… - Chemical biology & …, 2012 - Wiley Online Library
Ester bond hydrolysis of membrane phospholipids by Phospholipase A 2 and consequent
release of fatty acids are the initiating steps of inflammation. It is proposed in this study that the …

Cellular calcium signaling in the aging brain

…, S Gunasekaran, S Lakshmi, C Sadasivan… - Journal of chemical …, 2019 - Elsevier
Aging in the biological system is an irreversible process. In the initial stages of lifespan aging
improves survival skills of an organism while in the later stages aging reduce the survival …

Endoluminal scaffolds for vascular reconstruction and exclusion of aneurysms from the cerebral circulation

BB Lieber, C Sadasivan - Stroke, 2010 - Am Heart Assoc
… Devices E and C effected the lowest mean hydrodynamic circulation, mean energy (Figure
3), and peak energy compared with the others. In summary, devices E and C scored the best …

An original flow diversion device for the treatment of intracranial aneurysms: evaluation in the rabbit elastase-induced model

C Sadasivan, L Cesar, J Seong, A Rakian, Q Hao… - Stroke, 2009 - Am Heart Assoc
Background and Purpose— The potential for successful treatment of intracranial aneurysms
by flow diversion is gradually being recognized in the clinical setting; however, the devices …

Bisphenol‐A can bind to human glucocorticoid receptor as an agonist: an in silico study

…, LM Divya, C Sadasivan - Journal of applied …, 2010 - Wiley Online Library
Bisphenol‐A (BPA) is a primary monomer in polycarbonate plastics and epoxy resins. BPA
may be released into the environment following its formation via hydrolysis of ester bonds of …

Drug repurposing against SARS-CoV-2 using E-pharmacophore based virtual screening, molecular docking and molecular dynamics with main protease as the target

…, J Abhithaj, D Francis, C Sadasivan - Journal of …, 2021 - Taylor & Francis
Since its first report in December 2019 from China, the COVID-19 pandemic caused by the
beta-coronavirus SARS-CoV-2 has spread at an alarming pace infecting about 5.59 million, …

Hemodynamics of flow diverters

R Dholakia, C Sadasivan… - Journal of …, 2017 - asmedigitalcollection.asme.org
Cerebral aneurysms are pathological focal evaginations of the arterial wall at and around
the junctions of the circle of Willis. Their tenuous walls predispose aneurysms to leak or …

Treatment of rabbit elastase-induced aneurysm models by flow diverters: development of quantifiable indexes of device performance using digital subtraction …

C Sadasivan, L Cesar, J Seong… - IEEE transactions on …, 2009 - ieeexplore.ieee.org
It has been known for more than a decade that intracranial aneurysms can be successfully
treated by deploying a porous meshed tube in the parent vessel of the aneurysm. Such …

Modeling the interaction of coils with the local blood flow after coil embolization of intracranial aneurysms

…, BB Lieber, C Sadasivan… - Journal of …, 2007 - asmedigitalcollection.asme.org
Aneurysmal recanalization and coil compaction after coil embolization of intracranial aneurysms
are seen in as many as 40% of cases. Higher packing density has been suggested to …