User profiles for C. Tolias

Christos Tolias

Consultant Neurosurgeon
Verified email at nhs.net
Cited by 5739

Critical appraisal of neuroprotection trials in head injury: what have we learned?

CM Tolias, MR Bullock - NeuroRx, 2004 - Springer
… the cysteine protease family, known as caspases, as important mediators of apoptosis and
the demonstration of their role in TBI,8 along with the realization that release of cytochrome c

Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage

…, J Woitzik, C Drenckhahn, J Steinbrink, C Tolias… - Brain, 2009 - academic.oup.com
… Figure 4C shows an epileptic seizure associated with physiological haemodynamic … (C)
Linear regression showing that the durations of cortical DC potential negativity and energy-…

[PDF][PDF] Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice

…, C Jung, L Hu, SI Mok, A Shah, EM Savner, C Tolias… - Neuron, 2010 - cell.com
… (B) Abnormal expression of c-Fos in the dorsal horn corresponds to the site of skin
lesions in Bhlhb5À/À mice. Immunostaining with anti-c-Fos antibodies reveals elevated c-Fos …

[HTML][HTML] Long-term antithrombotic therapy and risk of intracranial haemorrhage from cerebral cavernous malformations: a population-based cohort study, systematic …

SM Zuurbier, CR Hickman, CS Tolias… - The Lancet …, 2019 - thelancet.com
… 2017 guidelines found few data for the risk of antithrombotic (anticoagulant or antiplatelet)
therapy use in people with a CCM (class III, level C). We searched Ovid MEDLINE and …

In vitro models of neurotrauma

A Kumaria, CM Tolias - British journal of neurosurgery, 2008 - Taylor & Francis
Traumatic brain injury (TBI) continues to be an important cause of mortality and morbidity, but
its pathophysiology is no longer considered an instantaneous irreversible event occurring …

The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development

KF Tolias, JB Bikoff, CG Kane… - Proceedings of the …, 2007 - National Acad Sciences
… (C) Tiam1 interacts with the cytoplasmic domain of EphB2 in a kinase-dependent manner. …
3C). This result indicates that Tiam1 interacts with the cytoplasmic domain of EphB2 and …

Normobaric hyperoxia—induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective …

CM Tolias, M Reinert, R Seiler, C Gilman… - Journal of …, 2004 - thejns.org
… Periods A through C were used for a comparison between groups. The probability value
signifies statistical significance when the mean values of patient groups in Period B were …

Evaluation of outcomes among patients with traumatic intracranial hypertension treated with decompressive craniectomy vs standard medical care at 24 months: a …

…, J Milo, H Madder, J FitzGerald, C Tolias… - JAMA …, 2022 - jamanetwork.com
Importance Trials often assess primary outcomes of traumatic brain injury at 6 months.
Longer-term data are needed to assess outcomes for patients receiving surgical vs medical …

Dynamic metabolic response to multiple spreading depolarizations in patients with acute brain injury: an online microdialysis study

…, M Fabricius, C Tolias, C Pahl… - Journal of Cerebral …, 2010 - journals.sagepub.com
Spreading depolarizations (SDs) occur spontaneously with high incidence in patients with
acute brain injury. They can be detected by subdural electrocorticographic recordings. We …

Surgical management of traumatic brain injury: a comparative-effectiveness study of 2 centers

…, M Fabricius, B Mathern, C Pahl, CM Tolias… - Journal of …, 2014 - thejns.org
… VCU also made aggressive, early use of CSF drainage by ventriculostomy and hypothermia
(33C–34C) as a late salvage therapy, in contrast to KCH. Hyperventilation to PaCO2 < 35 …