Cognitive function is an important component of aging and predicts quality of life, functional
independence, and risk of institutionalization. Advances in our understanding of the role of …

Even though stroke presents as a variety of clinical syndromes, neuroimaging is the most
important biomarker to help differentiate between stroke subtypes and assess treatment …

Background Intravenous thrombolysis with alteplase bolus followed by infusion is a global
standard of care for patients with acute ischaemic stroke. We aimed to determine whether …

Background Nerinetide, an eicosapeptide that interferes with post-synaptic density protein
95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. …

… Finally, VCI trials may be based on an expectation of preventing symptomatic VCI (Figure
1C). Many such trials define patient eligibility based on clinically defined cerebrovascular …

Background and Purpose— Autopsy studies suggest that cerebral amyloid angiopathy (CAA)
is associated with cognitive impairment and risk for dementia. We analyzed …

Background— The effectiveness of specific systems changes to reduce DTN (door-to-needle)
time has not been fully evaluated. We analyzed the impact of 4 specific DTN time reduction …

… C. Zerna contributed to the study concept and design, acquisition, analysis, and interpretation
of the data, and revising the manuscript. Z. Assis contributed to the study concept and …

Background Respiratory infection can be an immediate precursor to stroke and myocardial
infarction. Influenza vaccination is associated with reduced risk of myocardial infarction and …

Importance The effectiveness and safety of intravenous alteplase given before or concurrently
with endovascular thrombectomy (EVT) is uncertain. Randomized clinical trials suggest …