Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation
CJ Hu, LY Wang, LA Chodosh, B Keith… - Molecular and cellular …, 2003 - Taylor & Francis
Transcriptional responses to hypoxia are primarily mediated by hypoxia-inducible factor (HIF),
a heterodimer of HIF-α and the aryl hydrocarbon receptor nuclear translocator subunits. …
a heterodimer of HIF-α and the aryl hydrocarbon receptor nuclear translocator subunits. …
HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth
The division, differentiation, and function of stem cells and multipotent progenitors are
influenced by complex signals in the microenvironment, including oxygen availability. Using a …
influenced by complex signals in the microenvironment, including oxygen availability. Using a …
[HTML][HTML] Thrombolysis guided by perfusion imaging up to 9 hours after onset of stroke
…, J Sturm, R Grimley, CH Chen, CJ Hu… - … England Journal of …, 2019 - Mass Medical Soc
Background The time to initiate intravenous thrombolysis for acute ischemic stroke is generally
limited to within 4.5 hours after the onset of symptoms. Some trials have suggested that …
limited to within 4.5 hours after the onset of symptoms. Some trials have suggested that …
[HTML][HTML] Clinical trials of new drugs for Alzheimer disease
LK Huang, SP Chao, CJ Hu - Journal of biomedical science, 2020 - Springer
Alzheimer disease (AD) accounts for 60–70% of dementia cases. Given the seriousness of
the disease and continual increase in patient numbers, developing effective therapies to treat …
the disease and continual increase in patient numbers, developing effective therapies to treat …
Acute postnatal ablation of Hif-2α results in anemia
M Gruber, CJ Hu, RS Johnson… - Proceedings of the …, 2007 - National Acad Sciences
Adaptive transcriptional responses to oxygen deprivation (hypoxia) are mediated by the
hypoxia-inducible factors (HIFs), heterodimeric transcription factors composed of two basic helix…
hypoxia-inducible factors (HIFs), heterodimeric transcription factors composed of two basic helix…
The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1α and HIF-2α
CJ Hu, A Sataur, L Wang, H Chen… - Molecular biology of the …, 2007 - Am Soc Cell Biol
The basic helix-loop-helix-Per-ARNT-Sim–proteins hypoxia-inducible factor (HIF)-1α and
HIF-2α are the principal regulators of the hypoxic transcriptional response. Although highly …
HIF-2α are the principal regulators of the hypoxic transcriptional response. Although highly …
[HTML][HTML] Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro
Alzheimer’s disease (AD) is the consequence of neuronal death and brain atrophy associated
with the aggregation of protein tau into fibrils. Thus disaggregation of tau fibrils could be a …
with the aggregation of protein tau into fibrils. Thus disaggregation of tau fibrils could be a …
Dynamic audit services for outsourced storages in clouds
…, H Hu, SS Yau, HG An, CJ Hu - IEEE transactions on …, 2011 - ieeexplore.ieee.org
In this paper, we propose a dynamic audit service for verifying the integrity of an untrusted
and outsourced storage. Our audit service is constructed based on the techniques, fragment …
and outsourced storage. Our audit service is constructed based on the techniques, fragment …
Botulinum toxin for diabetic neuropathic pain: a randomized double-blind crossover trial
…, JM Yu, WT Chen, IJ Tseng, HH Chang, CJ Hu - Neurology, 2009 - AAN Enterprises
Background: Diabetic neuropathy is a common complication in diabetes, with patients typically
experiencing diverse sensory symptoms including dysesthesias in the feet and usually …
experiencing diverse sensory symptoms including dysesthesias in the feet and usually …
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1α) and HIF-2α in stem cells
CJ Hu, S Iyer, A Sataur, KL Covello… - … and cellular biology, 2006 - Taylor & Francis
Transcriptional responses to hypoxia are primarily mediated by hypoxia-inducible factors (HIFs),
HIF-1α and HIF-2α. The HIF-1α and HIF-2α subunits are structurally similar in their DNA …
HIF-1α and HIF-2α. The HIF-1α and HIF-2α subunits are structurally similar in their DNA …
