… These procedures have also been applied to a number of practical problems (Chang and
Duncan, 2; Clough and Duncan, 3; Kulhawy and Duncan, 21, Kulhawy and Duncan, 22). In …

The retinoblastoma gene, a prototypic tumour-suppressor gene, encodes a nuclear phosphoprotein
(Rb). To understand better the role of Rb in development and in tumorigenesis, mice …

ContextDeficits in cerebral glucose utilization have been identified in patients with cognitive
dysfunction attributed to various disease processes, but their prognostic and diagnostic …

Somatic chromosomal deletions in cancer are thought to indicate the location of tumour
suppressor genes, by which a complete loss of gene function occurs through biallelic deletion, …

Though many individual transcription factors are known to regulate hematopoietic differentiation,
major aspects of the global architecture of hematopoiesis remain unknown. Here, we …

CD8 + T cells have a central role in antitumour immunity, but their activity is suppressed in
the tumour microenvironment 1 , 2 , 3 , 4 . Reactivating the cytotoxicity of CD8 + T cells is of …

Attenuation relationships are presented for peak acceleration and response spectral accelerations
from shallow crustal earthquakes. The relationships are based on strong motion data …

Vitamin K epoxide reductase (VKOR) is the target of warfarin, the most widely prescribed
anticoagulant for thromboembolic disorders. Although estimated to prevent twenty strokes per …

In this study, two varieties of tomatoes (Lycopersicon esculentum Mill.), “I-Tien-Hung (ITH)”
and “Sheng-Neu (SN)”, were used to study the effects of different drying processes, freeze-…

Mammalian cells acquire cholesterol from low-density lipoprotein (LDL) and from endogenous
biosynthesis. The roles of the Niemann-Pick type C1 protein in mediating the endosomal …