Serotonin (5-HT) neuron and neurotransmitter loss in normal aging and neuropsychiatric
diseases of late life may contribute to behavioral changes commonly observed in the elderly …

Mossa-Basha et al frequently travel to China and other regions with high infection rates. The
largest risk remains in older patient populations, as 71% of patients infected in Washington …

Functional imaging with positron emission tomography (PET) is playing an increasingly
important role in the diagnosis and staging of malignant disease, image-guided therapy planning…

A valid quantitative imaging method for the measurement of amyloid deposition in humans
could improve Alzheimer's disease (AD) diagnosis and antiamyloid therapy assessment. Our …

Context Cognitive impairment in late-life depression (LLD) is highly prevalent, disabling,
poorly understood, and likely related to long-term outcome. Objectives To determine the …

PET studies have been performed using the amyloid binding radiotracer Pittsburgh
Compound B (PIB). Previous quantitative analyses using arterial blood showed that the Logan …

Object No definitive treatment exists to restore lost brain function following a stroke. Transplantation
of cultured neuronal cells has been shown to be safe and effective in animal models …

BACKGROUND: Several lines of evidence support the possibility that disturbances of
dopamine (DA) function could contribute to alterations of weight, feeding, motor activity, and …

OBJECTIVE: The authors’ goal was to compare regional brain volumes in depressed elderly
subjects with those of nondepressed elderly subjects by using voxel-based morphometry. …

Due to the limited spatial resolution of positron emission tomography (PET), the accuracy of
quantitative measurements of regional metabolism or neuroreceptor concentration is …