The matrix metalloproteinase MMP-9/gelatinase B is upregulated in angiogenic dysplasias
and invasive cancers of the epidermis in a mouse model of multi-stage tumorigenesis elicited …

Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with
frequent histone H3 K27M mutations and recurrent alterations in PDGFRA and TP53. We …

Loss of E-cadherin has been associated with human cancers, and yet in the early mouse
embryo and the lactating mammary gland, the E-cadherin null state results in tissue dysfunction …

Co-expression and gene linkage have hampered elucidating the physiological relevance of
cadherins in mammalian tissues. Here, we combine conditional gene ablation and …

Hepatocellular carcinoma (HCC) is the most common primary liver tumor and represents the
third-leading cause of cancer-related death in the world. The incidence of HCC continues to …

Advances in multimodality therapy have led to childhood cancer cure rates over 80%.
However, surgery, chemotherapy, and radiotherapy may lead to debilitating or even fatal long‐…

Background This report documents the clinical characteristics, molecular grouping, and
outcome of young children with ependymoma treated prospectively on a clinical trial. Methods …

… Combination status was tested as a covariate upon the apparent clearance (CL/F) of each
compound using the likelihood ratio test. Brain concentrations were log transformed and …

Molecular alterations are increasingly being used to distinguish tumors with similar
histopathologic features but distinct clinical characteristics. Among IDH-wildtype and H3-wildtype (…

Background Hippocampal avoidance has been suggested as a strategy to reduce short-term
memory decline in adults receiving whole-brain radiation therapy (RT). The purpose of this …