The MTHFD1 p. Arg653Gln variant alters enzyme function and increases risk for congenital heart defects

KE Christensen, CV Rohlicek, GU Andelfinger… - Human …, 2009 - Wiley Online Library
Methylenetetrahydrofolate dehydrogenase)methenyltetrahydrofolate cyclohydrolase)formyltetrahydrofolate
synthetase (MTHFD1) is a trifunctional enzyme that interconverts …

Nuclear β-adrenergic receptors modulate gene expression in adult rat heart

G Vaniotis, D Del Duca, P Trieu, CV Rohlicek… - Cellular signalling, 2011 - Elsevier
Both β 1 - and β 3 -adrenergic receptors (β 1 ARs and β 3 ARs) are present on nuclear
membranes in adult ventricular myocytes. These nuclear-localized receptors are functional with …

Maternal in utero exposure to the endocrine disruptor di-(2-ethylhexyl) phthalate affects the blood pressure of adult male offspring

…, M McIntosh, CV Rohlicek… - Toxicology and applied …, 2013 - Elsevier
Di-(2-ethylhexyl) phthalate (DEHP) is used industrially to add flexibility to polyvinyl chloride (PVC)
polymers and is ubiquitously found in the environment, with evidence of prenatal, …

Natural history and surgical outcomes for isolated discrete subaortic stenosis in children

CV Rohlicek, SF del Pino, M Hosking, J Miro, JM Côté… - Heart, 1999 - heart.bmj.com
OBJECTIVE To document the natural history and surgical outcomes for discrete subaortic
stenosis in children. DESIGN Retrospective review. SETTING Tertiary care paediatric …

Decreased left ventricular function, myocarditis, and coronary arteriolar medial thickening following monocrotaline administration in adult rats

…, E Seifert, CV Rohlicek - Journal of Applied …, 2007 - journals.physiology.org
Decreased right as well as left ventricular function can be associated with pulmonary hypertension
(PH). Numerous investigations have examined cardiac function following induction of …

Hippocampal alterations and functional correlates in adolescents and young adults with congenital heart disease

K Fontes, CV Rohlicek, C Saint‐Martin… - Human brain …, 2019 - Wiley Online Library
There is a high prevalence of neurodevelopmental impairments in individuals living with
congenital heart disease (CHD) and the neural correlates of these impairments are not yet fully …

Attitudes and practices of cardiologists and surgeons who manage HLHS

…, CD Holly, FA Carnevale, H Justino, CV Rohlicek - …, 2010 - publications.aap.org
OBJECTIVE: We conducted a survey to determine which management options pediatric
cardiologists and cardiac surgeons in North America discuss and recommend when counseling …

[HTML][HTML] Quantification of apparent axon density and orientation dispersion in the white matter of youth born with congenital heart disease

K Easson, CV Rohlicek, JC Houde, G Gilbert… - Neuroimage, 2020 - Elsevier
Background White matter alterations have previously been demonstrated in adolescents born
with congenital heart disease (CHD) using diffusion tensor imaging (DTI). However, due to …

Oxygen transport in conscious newborn dogs during hypoxic hypometabolism

CV Rohlicek, C Saiki, T Matsuoka… - Journal of Applied …, 1998 - journals.physiology.org
We questioned whether the decrease in O 2 consumption (Vo 2 ) during hypoxia in
newborns is a regulated response or reflects a limitation in O 2 availability. Experiments were …

Risk of congenital heart defects is influenced by genetic variation in folate metabolism

KE Christensen, YF Zada, CV Rohlicek… - Cardiology in the …, 2013 - cambridge.org
Genetic disturbances in folate metabolism may increase risk for congenital heart defects. We
examined the association of heart defects with four polymorphisms in folate-related genes (…