Ollier disease and Maffucci syndrome are non-hereditary skeletal disorders characterized
by multiple enchondromas (Ollier disease) combined with spindle cell hemangiomas (Maffucci …

Purpose Bailey and Cushing established ependymoma as a brain tumour entity in the first
brain tumour classification (1926). Diagnosis of ependymomas is not subject to controversy as …

Hepatocyte nuclear factor 6 (HNF-6) is the prototype of a new class of cut homeodomain
transcription factors. During mouse development, HNF-6 is expressed in the epithelial cells that …

Among tumors classified as pilocytic astrocytoma (PA) in the Johns Hopkins Hospital Department
of Pathology files, we identified 18 cases with a distinctive monomorphous pilomyxoid …

Somatic mutations in TEK, the gene encoding endothelial cell tyrosine kinase receptor TIE2,
cause more than half of sporadically occurring unifocal venous malformations (VMs). Here, …

Background Histopathological grading of ependymoma has been controversial with respect
to its reproducibility and clinical significance. In a 3-phase study, we reviewed the pathology …

Gliomas such as oligodendrogliomas (ODG) and glioblastomas (GBM) are brain tumours
with different clinical outcomes. Histology-based classification of these tumour types is often …

No reliable classification is in clinical use for the therapeutic stratification of children with
ependymoma, such that disease risk might be identified and patients treated to ensure a …

CIC-fused sarcomas represent an emerging family of tumors, for long connected to the
Ewing family group of tumors, but underlined by distinct CIC fusions with different partners. 3′ …

Mutations in the endothelial cell (EC) tyrosine kinase receptor TIE2 cause inherited and
sporadic forms of venous malformation. The recurrent somatic mutation L914F and common …