User profiles for Chih-Liang Chin

Chih-Liang Chin

Merck
Verified email at merck.com
Cited by 2085

MRI diffusion coefficients in spinal cord correlate with axon morphometry

ED Schwartz, ET Cooper, Y Fan, AF Jawad, CL Chin… - …, 2005 - journals.lww.com
Following spinal cord injury, diffusion MRI (DWI) has been shown to detect injury and
functionally significant neuroprotection following treatment that otherwise would go undetected …

BirdcageBuilder: design of specified‐geometry birdcage coils with desired current pattern and resonant frequency

CL Chin, CM Collins, S Li… - Concepts in Magnetic …, 2002 - Wiley Online Library
A simple method for birdcage coil design (high pass, low pass, and band pass) is presented.
Rather than iteratively approaching the Larmor resonant frequency with known …

[HTML][HTML] CD4+ T Cells Mediate the Development of Liver Fibrosis in High Fat Diet-Induced NAFLD in Humanized Mice

…, KTE Chang, L Sun, SC Chang, CL Chin… - Frontiers in …, 2020 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) has been on a global rise. While animal models
have rendered valuable insights to the pathogenesis of NAFLD, discrepancy with patient data …

[HTML][HTML] Default-mode-like network activation in awake rodents

…, L Miller, Y Lee, GJ Marek, U Sakoglu, CL Chin… - PloS one, 2011 - journals.plos.org
During wakefulness and in absence of performing tasks or sensory processing, the default-mode
network (DMN), an intrinsic central nervous system (CNS) network, is in an active state. …

Biexponential diffusion attenuation in the rat spinal cord: computer simulations based on anatomic images of axonal architecture

CL Chin, FW Wehrli, SN Hwang… - … in Medicine: An …, 2002 - Wiley Online Library
Water diffusion in neurological tissues is known to possess multicomponent diffusion behavior.
The fractions of fast and slow apparent diffusion components have often been attributed …

An image‐based finite difference model for simulating restricted diffusion

SN Hwang, CL Chin, FW Wehrli… - Magnetic Resonance in …, 2003 - Wiley Online Library
Water diffusion in tissues is generally restricted and often anisotropic. Neural tissue is of
particular interest, since it is well known that injury alters diffusion in a characteristic manner. …

Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2, 2, 3, 3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4, 5-dimethyl-3H …

…, C Zhong, K Ryther, ME Gallagher, CL Chin… - … of Pharmacology and …, 2009 - ASPET
Studies demonstrating the antihyperalgesic and antiallodynic effects of cannabinoid CB 2
receptor activation have been largely derived from the use of receptor-selective ligands. Here, …

[HTML][HTML] Systematic evaluation of multiple qPCR platforms, NanoString and miRNA-Seq for microRNA biomarker discovery in human biofluids

…, L Zhou, R Zou, CM Khoo, ALS Chew, CL Chin… - Scientific reports, 2021 - nature.com
Aberrant miRNA expression has been associated with many diseases, and extracellular
miRNAs that circulate in the bloodstream are remarkably stable. Recently, there has been …

Awake rat pharmacological magnetic resonance imaging as a translational pharmacodynamic biomarker: metabotropic glutamate 2/3 agonist modulation of ketamine …

CL Chin, J Upadhyay, GJ Marek, SJ Baker… - … of Pharmacology and …, 2011 - ASPET
Neuroimaging techniques have been exploited to characterize the effect of N-methyl-d-aspartate
(NMDA) receptor antagonists on brain activation in humans and animals. However, …

Apparent diffusion coefficients in spinal cord transplants and surrounding white matter correlate with degree of axonal dieback after injury in rats

ED Schwartz, CL Chin, JS Shumsky… - American journal …, 2005 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Abnormal apparent diffusion coefficient (ADC) values in
injured spinal cord white matter and fibroblast transplants have been shown to correspond …