Long-term outcome and survival of surgically treated supratentorial low-grade glioma in adult patients
A Rezvan, D Christine, H Christian, Z Olga, E Lutz… - Acta …, 2009 - Springer
Purpose The appropriate management of low-grade gliomas is still a matter of debate. So far,
there are no randomized studies that analyze the impact of surgical resection on patient …
there are no randomized studies that analyze the impact of surgical resection on patient …
Clinical evaluation and follow-up results for intraoperative magnetic resonance imaging in neurosurgery
CR Wirtz, M Knauth, A Staubert, MM Bonsanto… - …, 2000 - journals.lww.com
OBJECTIVE: The use of intraoperative magnetic resonance imaging (MRI) in neurosurgery
has increased rapidly, and a variety of concepts have recently been presented. Although the …
has increased rapidly, and a variety of concepts have recently been presented. Although the …
Epidermal growth factor receptor inhibition for the treatment of glioblastoma multiforme and other malignant brain tumours
…, J Behnke-Mursch, A Unterberg, CR Wirtz - Cancer treatment …, 2006 - Elsevier
Gliomas are the most common primary central nervous system tumours and about 55% are
glioblastoma multiforme (GBM). Between 40% and 50% of GBM have dysregulated …
glioblastoma multiforme (GBM). Between 40% and 50% of GBM have dysregulated …
Tumor detection with 5-aminolevulinic acid fluorescence and Gd-DTPA–enhanced intraoperative MRI at the border of contrast-enhancing lesions: a prospective study …
Object High-grade gliomas (HGGs) and metastasis (MET) are the most common intracranial
lesions in neurosurgical routine. Both of them show an invasive growth pattern extending …
lesions in neurosurgical routine. Both of them show an invasive growth pattern extending …
Low-grade glioma surgery in intraoperative magnetic resonance imaging: results of a multicenter retrospective assessment of the German study group for …
…, M Mehdorn, AW Unterberg, K Rössler, CR Wirtz - …, 2016 - journals.lww.com
BACKGROUND: The ideal treatment strategy for low-grade gliomas (LGGs) is a
controversial topic. Additionally, only smaller single-center series dealing with the concept of …
controversial topic. Additionally, only smaller single-center series dealing with the concept of …
[HTML][HTML] Surgery for glioblastoma: impact of the combined use of 5-aminolevulinic acid and intraoperative MRI on extent of resection and survival
J Coburger, V Hagel, CR Wirtz, R König - PloS one, 2015 - journals.plos.org
Background There is rising evidence that in glioblastoma(GBM) surgery an increase of extent
of resection(EoR) leads to an increase of patient’s survival. Based on histopathological …
of resection(EoR) leads to an increase of patient’s survival. Based on histopathological …
Surgically induced intracranial contrast enhancement: potential source of diagnostic error in intraoperative MR imaging
M Knauth, N Aras, CR Wirtz, A Dörfler… - American journal …, 1999 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Intraoperative MR imaging is being used increasingly
during neurosurgical interventions. The aim of this study was to describe and classify different …
during neurosurgical interventions. The aim of this study was to describe and classify different …
Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis
…, L Nonnenmacher, G Karpel-Massler, CR Wirtz… - Clinical Cancer …, 2011 - AACR
Purpose: Searching for novel approaches to sensitize glioblastoma for cell death, we
investigated the proteasome inhibitor bortezomib. Experimental Design: The effect of bortezomib …
investigated the proteasome inhibitor bortezomib. Experimental Design: The effect of bortezomib …
Augmented reality–assisted ventriculostomy
M Schneider, C Kunz, A Pal'a, CR Wirtz… - Neurosurgical …, 2021 - thejns.org
OBJECTIVE Placement of a ventricular drain is one of the most common neurosurgical
procedures. However, a higher rate of successful placements with this freehand procedure is …
procedures. However, a higher rate of successful placements with this freehand procedure is …
[HTML][HTML] Intraoperative MRI-guided resection is not superior to 5-aminolevulinic acid guidance in newly diagnosed glioblastoma: a prospective controlled multicenter …
…, O Ganslandt, A Unterberg, CR Wirtz… - Journal of Clinical …, 2023 - ncbi.nlm.nih.gov
PURPOSE Prospective data suggested a superiority of intraoperative MRI (iMRI) over 5-aminolevulinic
acid (5-ALA) for achieving complete resections of contrast enhancement in …
acid (5-ALA) for achieving complete resections of contrast enhancement in …