We have evaluated the ability of various opioid agonists, including methadone, l-α-acetylmethadol
(LAAM), fentanyl, meperidine, codeine, morphine, and buprenorphine, to block the …

Numerous medications prolong the rate-corrected QT (QTc) interval and induce arrhythmias
by blocking ionic current through cardiac potassium channels composed of subunits …

Study Design. Retrospective. Objective. To assess the incidence of complications associated
with fluoroscopically guided percutaneous radiofrequency denervation of the lumbar facet …

Transdermal fentanyl is effective and well tolerated for the treatment of chronic pain caused
by malignancy and non-malignant conditions when administered according to the …

In cancer patients, cognitive impairment, psychological distress, and anxiety may accompany
and aggravate pain. Neuroleptics are frequently used to control these symptoms and may …

The successful use of methadone in cancer pain has been supported by numerous case
reports and clinical studies. Methadone is usually used as a second or third line opioid …

BACKGROUND Patients often are rotated from other opioids to methadone when side effects
occur before satisfactory analgesia is achieved. Various strategies have been proposed to …

Methadone is currently best known for its use as the maintenance drug in opioid addiction.
The main concern when using methadone for the treatment of pain is its long and …

BACKGROUND Therapeutic fentanyl blood levels are reached approximately 12–16 hours
after the initial application of transdermal fentanyl patches. For this reason, fentanyl patches …

Clinical and animal data suggest that antihistamines may have efficacy in the management
of pain. While many mechanisms of action have been proposed for the analgesic action of …