User profiles for D Chien

David Chien, MD

- Verified email at abbvie.com - Cited by 2224

Diana M. Chien

- Verified email at mit.edu - Cited by 636

BAY 43-9006: preclinical data

S Wilhelm, DS Chien - Current pharmaceutical design, 2002 - ingentaconnect.com
The drug design and discovery efforts described in the previous section led to the development
of a novel, small molecule Raf-1 kinase inhibitor, BAY 43-9006, which belongs to a class …

Tumor cell vascular mimicry: Novel targeting opportunity in melanoma

…, EA Seftor, REB Seftor, JT Chao, DS Chien… - Pharmacology & …, 2016 - Elsevier
… Tumor cell vasculogenic mimicry (VM), also known as vascular mimicry, describes the
plasticity of aggressive cancer cells forming de novo vascular networks and is associated with the …

[HTML][HTML] Associations and dynamics of Vibrionaceae in the environment, from the genus to the population level

AF Takemura, DM Chien, MF Polz - Frontiers in microbiology, 2014 - frontiersin.org
The Vibrionaceae, which encompasses several potential pathogens, including V. cholerae,
the causative agent of cholera, and V. vulnificus, the deadliest seafood-borne pathogen, are …

Lipophilicity influence on conjunctival drug penetration in the pigmented rabbit: a comparison with corneal penetration

W Wang, H Sasaki, DS Chien, VHL Lee - Current eye research, 1991 - Taylor & Francis
The influence of lipophilicity on the conjunctival penetration of beta blockers in the pigmented
rabbit was investigated and compared with that on corneal penetration. The beta blockers …

Corneal and conjunctival/scleral penetration of p-aminoclonidine, AGN 190342, and clonidine in rabbit eyes

DS Chien, JJ Homsy, C Gluchowski… - Current eye …, 1990 - Taylor & Francis
d i ne and p-ami nocl oni d i ne in most ocular tissues. The total tissue drug concentrations
absorbed via the corneal and conjunctival/scleral routes followed a different rank order …

Fast magnetic resonance diffusion‐weighted imaging of acute human stroke

S Warach, D Chien, W Li, M Ronthal, RR Edelman - Neurology, 1992 - AAN Enterprises
Rapid MRI of the molecular diffusion of water demonstrated cerebral infarcts in 32 patients.
We studied these patients at various times following the onset of ischemic symptoms and …

Vaccination of chimpanzees against infection by the hepatitis C virus.

…, G Kuo, R Ralston, A Weiner, D Chien… - Proceedings of the …, 1994 - National Acad Sciences
A high incidence of community-acquired hepatitis C virus infection that can lead to the
progressive development of chronic active hepatitis, liver cirrhosis, and primary hepatocellular …

Fast selective black blood MR imaging.

RR Edelman, D Chien, D Kim - Radiology, 1991 - pubs.rsna.org
To overcome the problems associated with gradient-echo (GRE) magnetic resonance (MR)
angiography ("bright blood" imaging) and "black blood" imaging with presaturated spin-echo …

[PDF][PDF] The aggressive victim of bullying

D Schwartz, LJ Proctor, DH Chien - … in school: The plight of the …, 2001 - stopsuicide.ch
Theoretical perspectives on bully/victim problems often incorporate a conceptualization of
the persistently targeted child as submissive, inhibited, or socially withdrawn (Perry, Perry, & …

Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807

DT Chien, S Bahri, AK Szardenings… - Journal of …, 2013 - content.iospress.com
Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked
to the degree of cognitive impairment in Alzheimer's disease. We have developed a novel …