Neuroradiologists may encounter, on a daily basis, a challenging diversity of neurologic
disorders, including stroke, trauma, epilepsy, and even neurodegenerative conditions, such as …

Neuroradiologists generally do not fully appreciate the importance of the territory of the
ascending pharyngeal artery. The ascending pharyngeal artery is a small but important artery …

Wnt growth factors mediate cell fate determination during embryogenesis and in the renewal
of tissues in the adult. Wnts act by stabilizing cellular levels of the transcriptional coactivator …

Targeted protein degradation has exploded over the past several years due to preclinical
and early clinical therapeutic success of numerous compounds, and the emergence of new …

TET proteins convert 5‐methylcytosine to 5‐hydroxymethylcytosine, an emerging dynamic
epigenetic state of DNA that can influence transcription. Evidence has linked TET1 function to …

Dynamic interactions between proteins comprise a key mechanism for temporal control of
cellular function and thus hold promise for development of novel drug therapies. It remains …

The transcription factor HIF1A is a key mediator of the cellular response to hypoxia. Despite
the importance of HIF1A in homeostasis and various pathologies, little is known about how it …

Bivalent proteolysis-targeting chimeras (PROTACs) drive protein degradation by simultaneously
binding a target protein and an E3 ligase and forming a productive ternary complex. We …

The two tandem bromodomains of the BET (bromodomain and extraterminal domain) proteins
enable chromatin binding to facilitate transcription. Drugs that inhibit both bromodomains …

Developing PROTACs to redirect the ubiquitination activity of E3 ligases and potently degrade
a target protein within cells can be a lengthy and unpredictable process, and it remains …