User profiles for D. Shih

David JH Shih

Assistant Professor, School of Biomedical Sciences, University of Hong Kong
Verified email at hku.hk
Cited by 12175

HDL and the inflammatory response induced by LDL-derived oxidized phospholipids

…, LW Castellani, S Reddy, D Shih, W Shi… - … , and vascular biology, 2001 - Am Heart Assoc
Oxidation of low density lipoprotein (LDL) phospholipids containing arachidonic acid at the
sn-2 position occurs when a critical concentration of “seeding molecules” derived from the …

The yin and yang of oxidation in the development of the fatty streak: a review based on the 1994 George Lyman Duff Memorial Lecture

…, SY Hama, MC Territo, AJ Lusis, DM Shih… - … , and vascular biology, 1996 - Am Heart Assoc
Shih and colleagues 92 found that HDL isolated from either the fatty … Shih and colleagues
92 reported that paraoxonase activity … Shih and colleagues 92 cloned the mouse paraoxonase …

[HTML][HTML] Immunopathology of inflammatory bowel disease

…, LB Zheng, Y Kanazawa, DQ Shih - World journal of …, 2014 - ncbi.nlm.nih.gov
… The epithelial layer is renewed every 2-3 d with a balance of proliferation of epithelial cells
in the crypts and migration down the villi in the small intestine or onto the surface of the colon …

Simplified models for LHC new physics searches

…, J Shelton, D Shih, J Shu, D Silverstein… - Journal of Physics G …, 2012 - iopscience.iop.org
This document proposes a collection of simplified models relevant to the design of new-physics
searches at the Large Hadron Collider (LHC) and the characterization of their results. …

Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice

…, YS Shi, C Park, LW Castellani, AJ Lusis, DM Shih - Circulation, 2002 - Am Heart Assoc
Background— Serum paraoxonase (PON1), an enzyme carried on HDL, inhibits LDL oxidation,
and in human population studies, low PON1 activity is associated with atherosclerosis. …

[HTML][HTML] Dissecting the genomic complexity underlying medulloblastoma

…, V Benes, P van Sluis, J Koster, R Volckmann, D Shih… - Nature, 2012 - nature.com
Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain
stem. It is the most common malignant brain tumour in children, and shows tremendous …

[HTML][HTML] Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

…, T Zichner, J Weischenfeldt, N Jäger, M Remke, D Shih… - Cell, 2012 - cell.com
Genomic rearrangements are thought to occur progressively during tumor development.
Recent findings, however, suggest an alternative mechanism, involving massive chromosome …

Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis

DM Shih, L Gu, YR Xia, M Navab, WF Li, S Hama… - Nature, 1998 - nature.com
… a–d, HDL from PON1 null mice fails to protect against LDL oxidation. Co-cultured cells
were treated with various combinations of medium alone (none), human LDL (hLDL), wild-type …

Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions

…, Z Shahrokh, S Marsters, K Achilles, D Shih… - Nature medicine, 2001 - nature.com
… We assessed potential hepatotoxicity in a further study, by dosing vehicle or Apo2L/TRAIL.0
at 100 mg/kg/d over 5 d (n = 12/group). There were no notable differences between the …

[HTML][HTML] Subgroup-specific structural variation across 1,000 medulloblastoma genomes

PA Northcott, DJH Shih, J Peacock, L Garzia… - Nature, 2012 - nature.com
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …