Background The timing and indications for surgical intervention to prevent systemic embolism
in infective endocarditis remain controversial. We conducted a trial to compare clinical …

This review summarizes relevant studies concerning uric acid and possible links to hypertension,
renal disease, and cardiovascular disease. Whether uric acid is an independent risk …

An elevation in circulating serum uric acid is strongly associated with the development of
hypertension and renal disease, but whether uric acid has a causal role or whether it simply …

The hCHK2 gene encodes the human homolog of the yeast Cds1 and Rad53 G 2 checkpoint
kinases, whose activation in response to DNA damage prevents cellular entry into mitosis. …

Hyperuricemia is associated with hypertension, vascular disease, renal disease, and
cardiovascular events. In this report, we review the epidemiologic evidence and potential …

Background— High-resolution visualization of atherosclerotic plaque morphology may be
essential for identifying coronary plaques that cause acute coronary events. Optical coherence …

Objectives : The aim of this study was to evaluate the feasibility and the ability of intravascular
optical coherence tomography (OCT) to visualize the components of coronary plaques in …

Previous studies have reported that uric acid stimulates vascular smooth muscle cell (VSMC)
proliferation in vitro. We hypothesized that uric acid may also have direct proinflammatory …

ABSTRACT. Hyperuricemia is associated with renal disease, but it is usually considered a
marker of renal dysfunction rather than a risk factor for progression. Recent studies have …

Currently, we are experiencing an epidemic of cardiorenal disease characterized by
increasing rates of obesity, hypertension, the metabolic syndrome, type 2 diabetes, and kidney …