User profiles for D.A. Wolk

Dave Wolk

Professor of Neurology, University of Pennsylvania
Verified email at uphs.upenn.edu
Cited by 22165

Vascular disease and dementias: paradigm shifts to drive research in new directions

MA Kling, JQ Trojanowski, DA Wolk, VMY Lee… - Alzheimer's & …, 2013 - Elsevier
Vascular disease was once considered the principal cause of aging-related dementia. More
recently, however, research emphasis has shifted to studies of progressive …

Arterial spin labeling MRI: an emerging biomarker for Alzheimer's disease and other neurodegenerative conditions

DA Wolk, JA Detre - Current opinion in neurology, 2012 - journals.lww.com
ASL MRI is just beginning to be applied more widely to various neurodegenerative conditions.
Initial data suggest that this methodology may provide similar information to FDG PET, but …

The National Institute on Aging and the Alzheimer's Association research framework for Alzheimer's disease: perspectives from the research roundtable

…, SM Resnick, G Romano, AC van Harten, DA Wolk… - Alzheimer's & …, 2018 - Elsevier
The Alzheimer's Association's Research Roundtable met in November 2017 to explore the
new National Institute on Aging and the Alzheimer's Association Research Framework for …

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis

…, G Waldemar, A Wallin, ÅK Wallin, J Wiltfang, DA Wolk… - Jama, 2015 - jamanetwork.com
Importance Cerebral amyloid-β aggregation is an early pathological event in Alzheimer
disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid …

Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis

…, KS Frederiksen, AS Fleisher, MA Mintun, DA Wolk… - Jama, 2015 - jamanetwork.com
… Dr Wolk reports consulting for GE Healthcare and being a site private investigator for a clinical
trial supported by AVID/Lilly. Dr Rinne reports receiving grant funding from Sigrid Juselius …

Automated volumetry and regional thickness analysis of hippocampal subfields and medial temporal cortical structures in mild cognitive impairment

…, L Mancuso, D Kliot, SR Das, DA Wolk - Human brain …, 2015 - Wiley Online Library
We evaluate a fully automatic technique for labeling hippocampal subfields and cortical
subregions in the medial temporal lobe in in vivo 3 Tesla MRI. The method performs …

Comparative accuracies of two common screening instruments for classification of Alzheimer's disease, mild cognitive impairment, and healthy aging

DR Roalf, PJ Moberg, SX Xie, DA Wolk, ST Moelter… - Alzheimer's & …, 2013 - Elsevier
Background The aim of this study was to compare the utility and diagnostic accuracy of the
Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) in the …

Amyloid imaging in mild cognitive impairment subtypes

DA Wolk, JC Price, JA Saxton, BE Snitz… - Annals of Neurology …, 2009 - Wiley Online Library
Objective We utilized the amyloid imaging ligand Pittsburgh Compound B (PiB) to determine
the presence of Alzheimer's disease (AD) pathology in different mild cognitive impairment (…

Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease

…, AS Wahed, J Saxton, RA Sweet, DA Wolk… - Journal of Neurology …, 2009 - jnnp.bmj.com
Background: Patients using cholinesterase inhibitors (ChEIs) have a delay in nursing home (NH)
admission compared with those who were not using the medication. There are no long-…

[HTML][HTML] Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan

…, MS Albert, HJ Grabe, SM Resnick, RN Bryan, DA Wolk… - NeuroImage, 2020 - Elsevier
As medical imaging enters its information era and presents rapidly increasing needs for big
data analytics, robust pooling and harmonization of imaging data across diverse cohorts with …