MicroRNAs (miRNAs) are noncoding RNAs that suppress translation of specific mRNAs.
The miRNA machinery interacts with fragile X mental retardation protein (FMRP), which …

The molecular mechanisms that determine the size and complexity of the neuronal dendritic
tree are unclear. Here, we show that the phosphoinositide-3′ kinase (PI3K)–Akt–…

… Consistent with this idea, overexpression of constitutively active Rap2 mutant in neurons
leads to a similar spine phenotype characterized by irregular thin protrusions (DP, unpublished …

Few patients with head and neck cancer go through diagnosis, staging, treatment, and
surveillance without at least one imaging study to aid in each one of these steps. With the …

Mitochondrial morphology within cells is controlled by precisely regulated rates of fusion
and fission [1–4]. During programmed cell death (PCD), mitochondria undergo extensive …

Homeostatic plasticity keeps neuronal spiking output within an optimal range in the face of
chronically altered levels of network activity. Little is known about the underlying molecular …

Mammalian Drp1 is a dynamin-like GTPase required for mitochondrial fission. Although it
exists primarily as a cytosolic homo-tetramer in vivo, it can also self-assemble into higher order …

Homeostatic plasticity mechanisms stabilize the activity of a neuron or neuronal circuit during
prolonged periods of increased network activity and have been proposed to function in the …

TGN is a rare unilateral episodic facial pain syndrome affecting the CN V and is characterized
by paroxysmal lancinating shocklike pain attacks typically evoked by touch. With …

The ubiquitin-proteasome pathway (UPP) regulates synaptic function, but little is known
about specific UPP targets and mechanisms in mammalian synapses. We report here that the …