Background Lidocaine has been the initial antiarrhythmic drug treatment recommended for
patients with ventricular fibrillation that is resistant to conversion by defibrillator shocks. We …

Background Platelet-activating factor (PAF) is an important mediator of anaphylaxis in
animals, and interventions that block PAF prevent fatal anaphylaxis. The roles of PAF and PAF …

Background In this randomized, double-blind, placebo-controlled trial, we studied the
effectiveness of prednisone in reducing the risk of relapse after outpatient exacerbations of chronic …

Background There is much controversy about the use of computed tomography (CT) for
patients with minor head injury. We aimed to develop a highly sensitive clinical decision rule for …

ContextHigh levels of variation and inefficiency exist in current clinical practice regarding
use of cervical spine (C-spine) radiography in alert and stable trauma patients.ObjectiveTo …

The management of patients with severe brain injury falls within the disciplines of emergency
medical services, trauma, critical care, neurology and neurosurgery. Consultation and …

Background The Canadian C-Spine (cervical-spine) Rule (CCR) and the National Emergency
X-Radiography Utilization Study (NEXUS) Low-Risk Criteria (NLC) are decision rules to …

ContextCurrent use of cranial computed tomography (CT) for minor head injury is increasing
rapidly, highly variable, and inefficient. The Canadian CT Head Rule (CCHR) and New …

… Contributors: Bert Lauwers and Dan Cass oversaw the coroner’s review; Navindra Persaud
… , Dorothy Zwolakowski, Bert Lauwers and Dan Cass revised the manuscript critically for …

Mutations in the gene encoding the endothelin receptor type B (EDNRB) produce congenital
aganglionic megacolon and pigment abnormalities in mice and humans. Here we report a …