Background Alterations in fibroblast growth factor receptor 2 (FGFR2) have emerged as
promising drug targets for intrahepatic cholangiocarcinoma, a rare cancer with a poor prognosis. …

BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) is an advanced MR technique
that describes the movement of water molecules by using two metrics, mean diffusivity (…

Checkpoint inhibitor (CPI) therapies provide limited benefit to patients with tumors of low
immune reactivity. T cell-inducing vaccines hold promise to exert long-lasting disease control in …

BACKGROUND Biliary tract cancers (BTCs) typically present at an advanced stage, and
systemic chemotherapy is often of limited benefit. METHODS Hybrid capture–based …

Importance Administration of gemcitabine-cisplatin, the current standard therapy for advanced
biliary tract cancers, results in median progression-free survival and overall survival of 8.0 …

PURPOSE: To determine whether diffusion-tensor magnetic resonance (MR) imaging metrics
of peritumoral edema can be used to differentiate intra- from extraaxial lesions, metastatic …

Importance The treatment landscape for advanced hepatocellular carcinoma (HCC) has
recently changed and become relatively confusing. Head-to-head comparisons between most …

Background Regorafenib confers an overall survival benefit in patients with refractory metastatic
colorectal cancer; however, the adverse event profile of regorafenib has limited its use. …

Biliary tract cancers (BTCs) are rare gastrointestinal malignancies that involve the liver and
biliary tract. Despite their being uncommon, there has been an increase in their incidence, …

How effective are “smart” sanctions in imposing costs on an adversary? We consider this
question in a model where a targeted regime may choose to “shield” strategically important …