Cerebral X-linked adrenoleukodystrophy (X-ALD) is a disorder of very-long-chain fatty acid
metabolism, adrenal insufficiency, and cerebral demyelination. Death occurs within 2 to 5 …

PURPOSE To develop a scoring method for brain observations in patients with X-linked
adrenoleukodystrophy. METHODS One hundred seventy-five brain MR scans in 83 male …

Background Globoid-cell leukodystrophy is caused by a deficiency of galactocerebrosidase,
which results in progressive central nervous system deterioration. We investigated whether …

MR changes of cerebral ischemia have been shown to occur as early as 1-2 hr after vessel
occlusion in experimental models of stroke. However, the MR findings in the early stages of …

Background: X-linked adrenoleukodystrophy (X-ALD) has variants with widely different
outcomes, hampering clinical counseling and evaluation of therapies. Objective: To evaluate the …

Objectives To identify asymptomatic boys with X-linked adrenoleukodystrophy who have a
normal magnetic resonance image (MRI), and to assess the effect of 4:1 glyceryl trioleate–…

Our objective was to study the phenotype evolution of X‐linked adrenoleukodystrophy (X‐ALD)
and the relation between axonal degeneration and cerebral demyelination. Although …

Metronidazole, a 5-nitroimidazole widely used for treatment of trichomoniasis, giardiasis,
amebiasis, and anaerobic infections, produces a number of neurologic side effects including …

BACKGROUND AND PURPOSE: Early assignment of disease progression among patients
with X-linked adrenoleukodystrophy (ALD) is critical for the appropriate selection of effective …

BACKGROUND AND PURPOSE: Our purpose was to determine the characteristic MR
features of early-onset (before age 2 years) versus late-onset (after age 2 years) globoid cell …