Learning the parts of objects by non-negative matrix factorization
Is perception of the whole based on perception of its parts? There is psychological 1 and
physiological 2 , 3 evidence for parts-based representations in the brain, and certain …
physiological 2 , 3 evidence for parts-based representations in the brain, and certain …
A positive role for histone acetylation in transcription factor access to nucleosomal DNA
Acetylation of the N-terminal tails of the core histones directly facilitates the recognition by
TFlllA of the 5s RNA gene wlthin model chromatin templates. This effect is independent of a …
TFlllA of the 5s RNA gene wlthin model chromatin templates. This effect is independent of a …
Current concepts in the diagnosis and management of cytokine release syndrome
DW Lee, R Gardner, DL Porter… - Blood, The Journal …, 2014 - ashpublications.org
As immune-based therapies for cancer become potent, more effective, and more widely
available, optimal management of their unique toxicities becomes increasingly important. …
available, optimal management of their unique toxicities becomes increasingly important. …
Algorithms for non-negative matrix factorization
Non-negative matrix factorization (NMF) has previously been shown to be a useful decomposition
for multivariate data. Two different multi-plicative algorithms for NMF are analyzed. …
for multivariate data. Two different multi-plicative algorithms for NMF are analyzed. …
[HTML][HTML] Stan: A probabilistic programming language
Stan is a probabilistic programming language for specifying statistical models. A Stan program
imperatively defines a log probability function over parameters conditioned on specified …
imperatively defines a log probability function over parameters conditioned on specified …
T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
DW Lee, JN Kochenderfer, M Stetler-Stevenson… - The Lancet, 2015 - thelancet.com
Background Chimeric antigen receptor (CAR) modified T cells targeting CD19 have shown
activity in case series of patients with acute and chronic lymphocytic leukaemia and B-cell …
activity in case series of patients with acute and chronic lymphocytic leukaemia and B-cell …
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
Loss of heterozygosity on chromosome 9p21 is one of the most frequent genetic alterations
identified in human cancer. The rate of point mutations of p16, a candidate suppressor gene …
identified in human cancer. The rate of point mutations of p16, a candidate suppressor gene …
[HTML][HTML] ASTCT consensus grading for cytokine release syndrome and neurologic toxicity associated with immune effector cells
DW Lee, BD Santomasso, FL Locke, A Ghobadi… - Biology of blood and …, 2019 - Elsevier
Chimeric antigen receptor (CAR) T cell therapy is rapidly emerging as one of the most promising
therapies for hematologic malignancies. Two CAR T products were recently approved …
therapies for hematologic malignancies. Two CAR T products were recently approved …
Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastases
A Taguchi, DC Blood, G del Toro, A Canet, DC Lee… - Nature, 2000 - nature.com
The receptor for advanced glycation end products (RAGE), a multi-ligand member of the
immunoglobulin superfamily of cell surface molecules 1 , 2 , interacts with distinct molecules …
immunoglobulin superfamily of cell surface molecules 1 , 2 , interacts with distinct molecules …
Genetic progression model for head and neck cancer: implications for field cancerization
…, H Nawroz, G Clayman, S Piantadosi, R Corio, D Lee… - Cancer research, 1996 - AACR
A genetic progression model of head and neck squamous cell carcinoma has not yet been
elucidated, and the genetic basis for “field cancerization” of the aerodigestive tract has also …
elucidated, and the genetic basis for “field cancerization” of the aerodigestive tract has also …
