This first-in-man imaging study evaluated the safety and feasibility of hyperpolarized [1- 13 C]pyruvate
as an agent for noninvasively characterizing alterations in tumor metabolism for …

Background Congenital heart disease in newborns is associated with global impairment in
development. We characterized brain metabolism and microstructure, as measures of brain …

PURPOSE: To evaluate if three-dimensional hydrogen-1 magnetic resonance spectroscopic
imaging (3D MRSI) when combined with a clinical MR imaging examination could …

PURPOSE: To assess the efficacy of combined magnetic resonance (MR) imaging and three-dimensional
(3D) proton MR spectroscopic imaging in the detection and localization of …

A major challenge in cancer biology is to monitor and understand cancer metabolism in vivo
with the goal of improved diagnosis and perhaps therapy. Because of the complexity of …

A large body of published work shows that proton (hydrogen 1 [ 1 H]) magnetic resonance (MR)
spectroscopy has evolved from a research tool into a clinical neuroimaging modality. …

An extraordinary new technique using hyperpolarized 13 C-labeled pyruvate and taking
advantage of increased glycolysis in cancer has the potential to improve the way magnetic …

PURPOSE We developed a scoring system for the assessment of perinatal asphyxia as
depicted on MR images. METHODS Four scoring systems were derived to evaluate MR images …

Diffusion tensor imaging (DTI) accurately delineates white matter pathways when the Gaussian
model of diffusion is valid. However, DTI yields erroneous results when diffusion takes on …

BACKGROUND AND PURPOSE: Tumor progression is often difficult to distinguish from
nonneoplastic treatment response on the basis of MR images alone. This study correlates …