The 2016 World Health Organization Classification of Tumors of the Central Nervous System
is both a conceptual and practical advance over its 2007 predecessor. For the first time, the …

The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS),
published in 2021, is the sixth version of the international standard for the classification of …

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young children …

Major discoveries in the biology of nervous system tumors have raised the question of how
non‐histological data such as molecular information can be incorporated into the next W orld …

cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor
Taxonomy) was established to evaluate and make practical recommendations on recent …

Mutations in OPA1, a dynamin-related GTPase involved in mitochondrial fusion, cristae
organization and control of apoptosis, have been linked to non-syndromic optic neuropathy …

Pituitary adenomas are currently classified by histological, immunocytochemical and
numerous ultrastructural characteristics lacking unequivocal prognostic correlations. We …

The central neurocytoma is a supratentorial, often calcified brain tumour affecting young
adults and is typically located in the lateral ventricles in the region of the foramen of Monro. …

Purpose To assess the prognostic role of clinical parameters and histology in early childhood
medulloblastoma. Patients and Methods Clinical and histologic data from 270 children …

The major changes in brain tumor classification arise through the World Health Organization
(WHO) classification update process. To provide possible guidelines for practicing …