… Genomic accomplishments across the domains are portrayed by hypothetical, highly
schematized density plots (each blue dot reflecting a single research accomplishment, with green, …

With the completion of the human genome sequence, attention turned to identifying and
annotating its functional DNA elements. As a complement to genetic and comparative genomics …

… coli are highly homologous, yet the Shigella T3SS is more similar to the Salmonella T3SS
than it is to systems found in the pathogens enterohemorrhagic E. coli and enteropathogenic E…

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

Genome-wide association studies have identified thousands of loci for common diseases,
but, for the majority of these, the mechanisms underlying disease susceptibility remain …

The lack of reproducibility of scientific studies has caused growing concern over the credibility
of claims of new discoveries based on ‘statistically significant’findings. There has been …

… In Finland, similar to the other Nordic countries, there are nationwide electronic health
registers that were originally established primarily for administrative purposes to monitor the …

The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional elements
in the human genome sequence. The pilot phase of the Project is focused on a specified …

… We thank the volunteers who participated in this study; E. Bassett for assistance with sample
collection; members of the Segre laboratory for their underlying contributions; M. Udey, N. …

To identify genes involved in cardiac arrhythmia, we investigated patients with long OT
syndrome (LOT), an inherited disorder causing sudden death from a ventricular tachyarrhythmia, …