Background Cerebral amyloid angiopathy (CAA) is an age-related small vessel disease,
characterised pathologically by progressive deposition of amyloid β in the cerebrovascular wall. …

Cell-free circulating tumour DNA (ctDNA) in plasma has been shown to be informative of the
genomic alterations present in tumours and has been used to monitor tumour progression …

The brain microenvironment imposes a particularly intense selective pressure on metastasis-initiating
cells, but successful metastases bypass this control through mechanisms that are …

Glioma-initiating cells (GICs), also called glioma stem cells, are responsible for tumor initiation,
relapse, and therapeutic resistance. Here, we show that TGF-β inhibitors, currently under …

Brain metastases are associated with a dismal prognosis. Whether brain metastases harbor
distinct genetic alterations beyond those observed in primary tumors is unknown. We …

In advanced cancer, including glioblastoma, the transforming growth factor β (TGF-β)
pathway acts as an oncogenic factor and is considered to be a therapeutic target. Using a …

Purpose: Diffuse gliomas are the most common primary tumor of the brain and include
different subtypes with diverse prognosis. The genomic characterization of diffuse gliomas …

In advanced cancer, including glioblastoma, the TGFβ pathway acts as an oncogenic factor.
Some tumors exhibit aberrantly high TGFβ activity, and the mechanisms underlying this …

… b, e, f WES analysis of brain tumour DNA and CSF cfDNA before surgery (CSF1) and
during follow-up (CSF2). b, e Heatmap representing the mutations identified; VAF values <10% …

The detailed molecular characterization of lethal cancers is a prerequisite to understanding
resistance to therapy and escape from cancer immunoediting. We performed extensive multi-…