Pulmonary arterial hypertension (PAH) is clinically characterized by a sustained elevation in
mean pulmonary artery pressure leading to significant morbidity and mortality. The disorder …

Purpose Reports detailing the prognostic impact of TP53 mutations in medulloblastoma offer
conflicting conclusions. We resolve this issue through the inclusion of molecular subgroup …

Background International consensus recognises four medulloblastoma molecular subgroups:
WNT (MB WNT ), SHH (MB SHH ), group 3 (MB Grp3 ), and group 4 (MB Grp4 ), each …

Background— Abdominal aortic aneurysm (AAA) expansion is characterized by extracellular
matrix degradation and widespread inflammation. In contrast, the processes that …

… (NMF) to define metagenes, composite measures that reflect the methylation status of many
molecular features to describe the major biological effects within a data set, Schwalbe et al. […

We undertook a comprehensive clinical and biological investigation of serial medulloblastoma
biopsies obtained at diagnosis and relapse. Combined MYC family amplifications and …

Background— The fibrous cap of atherosclerotic plaques is composed predominantly of
type I and III collagen. Unstable carotid plaques are characterized by rupture of their cap, …

Molecular subclassification is rapidly informing the clinical management of medulloblastoma.
However, the disease remains associated with poor outcomes and therapy-associated late …

Immune-therapy is an attractive alternative therapeutic approach for targeting central nervous
system (CNS) tumors and the constituency of the Tumor Immune Microenvironment (TIME) …

Prokaryotic systematics provides the fundamental framework for microbiological research
but remains a discipline that relies on a labour- and time-intensive polyphasic taxonomic …