Coronavirus disease-2019 (COVID-19), a viral respiratory illness caused by the severe acute
respiratory syndrome-coronavirus-2 (SARS-CoV-2), may predispose patients to thrombotic …

Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

There is increasing evidence that coronavirus disease 2019 (COVID-19) produces more severe
symptoms and higher mortality among men than among women 1 , 2 , 3 , 4 – 5 . However…

COVID-19 manifests with a wide spectrum of clinical phenotypes that are characterized by
exaggerated and misdirected host immune responses 1 , 2 , 3 , 4 , 5 – 6 . Although …

The human brain vasculature is of great medical importance: its dysfunction causes disability
and death 1 , and the specialized structure it forms—the blood–brain barrier—impedes the …

We review the emergence of the new field of organ-on-a-chip (OOAC) engineering, from the
parent fields of tissue engineering and microfluidics. We place into perspective the tools and …

The vascular interface of the brain, known as the blood–brain barrier (BBB), is understood
to maintain brain function in part via its low transcellular permeability 1 , 2 – 3 . Yet, recent …

Tissue engineering using cardiomyocytes derived from human pluripotent stem cells holds
a promise to revolutionize drug discovery, but only if limitations related to cardiac chamber …

Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal
neoplasms of the hindbrain with strong links to early development of the hindbrain 1, 2, 3, 4. …

A nanoparticle magnetic resonance imaging (MRI) contrast agent was developed by
conjugation of more than 500 gadolinium chelate groups onto a viral capsid. The high density of …