Spinal cord injury is a devastating condition of the central nervous system (CNS), often resulting
in severe loss of tissue, functional impairment, and only limited repair. Studies over the …

Accumulating evidence points to the existence of a mechanism that may explain why
glaucomatous neuropathy continues to progress even after its primary cause, eg, high intraocular …

Purpose: This article presents the rationale and an experimental strategy for the development
of new treatment modalities for glaucomatous neuropathy. Accumulating evidence …

Autoimmunity to antigens of the central nervous system is usually considered detrimental. T
cells specific to a central nervous system self antigen, such as myelin basic protein, can …

Partial injury to the spinal cord can propagate itself, sometimes leading to paralysis
attributable to degeneration of initially undamaged neurons. We demonstrated recently that …

Primary damage caused by injury to the CNS is often followed by delayed degeneration of
initially spared neurons. Studies in our laboratory have shown that active or passive …

We recently reported that the posttraumatic spread of degeneration in the damaged optic
nerve can be attenuated by the adoptive transfer of autoimmune T cells specific to myelin basic …

PURPOSE: The neurodegenerative progression of glaucoma is considered to be related
not only to primary risk factors such as the elevation of intraocular pressure, but also to …

Object. A Phase I, open-label nonrandomized study was conducted to assess the safety and
tolerability of incubated autologous macrophages administered to patients with acute …

Our group recently demonstrated that autoimmune T cells directed against central nervous
system-associated myelin antigens protect neurons from secondary degeneration. We further …