User profiles for F Urano

Fumihiko Urano

Samuel E. Schechter Professor of Medicine, Washington University School of Medicine
Verified email at wustl.edu
Cited by 22420

Transcriptional and translational control in the Mammalian unfolded protein response

HP Harding, M Calfon, F Urano… - Annual review of cell …, 2002 - annualreviews.org
Urano, unpublished observations), suggesting that these two genes control more than …
gene expression program activated in the UPR (F. Urano, unpublished observations). As noted …

Endoplasmic reticulum stress and pancreatic β-cell death

SG Fonseca, J Gromada, F Urano - Trends in Endocrinology & Metabolism, 2011 - cell.com
In pancreatic β-cells, the endoplasmic reticulum (ER) is an important cellular compartment
for insulin biosynthesis, which accounts for half of the total protein production in these cells. …

IRE1 and efferent signaling from the endoplasmic reticulum

F Urano, A Bertolotti, D Ron - Journal of cell science, 2000 - journals.biologists.com
… However, we observed no consistent defect in either BiP or CHOP induction or activation
of IRE1α in presenilin-1 and presenilin-2 double-knockout cells (F. Urano and D. Ron, …

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

F Urano, XZ Wang, A Bertolotti, Y Zhang, P Chung… - science, 2000 - science.org
Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun
amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which …

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

M Calfon, H Zeng, F Urano, JH Till, SR Hubbard… - Nature, 2002 - nature.com
… We screened the F 2 progeny of ethylmethane sulphonate (… hsp-4::gfp, we screened the F 2
progeny of EMS-treated hsp-4:… then observing the phenotype of the F 1 progeny as described …

Autophagy is activated for cell survival after endoplasmic ReticulumStress

…, S Shiosaka, JA Hammarback, F Urano… - … and cellular biology, 2006 - Taylor & Francis
… Panels f to i are high magnification images of panels b to e, respectively. Typical
autophagosomes (arrows), autolysosomes (arrowheads), and multivesicular bodies (indicated by …

Measuring ER stress and the unfolded protein response using mammalian tissue culture system

CM Oslowski, F Urano - Methods in enzymology, 2011 - Elsevier
The endoplasmic reticulum (ER) functions to properly fold and process secreted and
transmembrane proteins. Environmental and genetic factors that disrupt ER function cause an …

[PDF][PDF] Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome

…, ST Hui, D Greiner, RJ Kaufman, R Bortell, F Urano - Cell metabolism, 2012 - cell.com
Recent clinical and experimental evidence suggests that endoplasmic reticulum (ER) stress
contributes to the life-and-death decisions of β cells during the progression of type 1 and …

Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones

T Yoneda, C Benedetti, F Urano… - Journal of cell …, 2004 - journals.biologists.com
Protein folding in the mitochondria is assisted by nuclear-encoded compartment-specific
chaperones but regulation of the expression of their encoding genes is poorly understood. We …

Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity

…, K Mizuseki, K Watanabe, F Urano… - Proceedings of the …, 2002 - National Acad Sciences
… (F) Suppression of neuronal differentiation by BMP4 and serum. Serum (instead of knockout
… 1F), suggesting that primate and mouse ES cells respond to the same positive (SDIA) and …