User profiles for F Urano
Fumihiko UranoSamuel E. Schechter Professor of Medicine, Washington University School of Medicine Verified email at wustl.edu Cited by 22420 |
Transcriptional and translational control in the Mammalian unfolded protein response
HP Harding, M Calfon, F Urano… - Annual review of cell …, 2002 - annualreviews.org
… Urano, unpublished observations), suggesting that these two genes control more than …
gene expression program activated in the UPR (F. Urano, unpublished observations). As noted …
gene expression program activated in the UPR (F. Urano, unpublished observations). As noted …
Endoplasmic reticulum stress and pancreatic β-cell death
SG Fonseca, J Gromada, F Urano - Trends in Endocrinology & Metabolism, 2011 - cell.com
In pancreatic β-cells, the endoplasmic reticulum (ER) is an important cellular compartment
for insulin biosynthesis, which accounts for half of the total protein production in these cells. …
for insulin biosynthesis, which accounts for half of the total protein production in these cells. …
IRE1 and efferent signaling from the endoplasmic reticulum
… However, we observed no consistent defect in either BiP or CHOP induction or activation
of IRE1α in presenilin-1 and presenilin-2 double-knockout cells (F. Urano and D. Ron, …
of IRE1α in presenilin-1 and presenilin-2 double-knockout cells (F. Urano and D. Ron, …
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun
amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which …
amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which …
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
M Calfon, H Zeng, F Urano, JH Till, SR Hubbard… - Nature, 2002 - nature.com
… We screened the F 2 progeny of ethylmethane sulphonate (… hsp-4::gfp, we screened the F 2
progeny of EMS-treated hsp-4:… then observing the phenotype of the F 1 progeny as described …
progeny of EMS-treated hsp-4:… then observing the phenotype of the F 1 progeny as described …
Autophagy is activated for cell survival after endoplasmic ReticulumStress
…, S Shiosaka, JA Hammarback, F Urano… - … and cellular biology, 2006 - Taylor & Francis
… Panels f to i are high magnification images of panels b to e, respectively. Typical
autophagosomes (arrows), autolysosomes (arrowheads), and multivesicular bodies (indicated by …
autophagosomes (arrows), autolysosomes (arrowheads), and multivesicular bodies (indicated by …
Measuring ER stress and the unfolded protein response using mammalian tissue culture system
CM Oslowski, F Urano - Methods in enzymology, 2011 - Elsevier
The endoplasmic reticulum (ER) functions to properly fold and process secreted and
transmembrane proteins. Environmental and genetic factors that disrupt ER function cause an …
transmembrane proteins. Environmental and genetic factors that disrupt ER function cause an …
[PDF][PDF] Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome
…, ST Hui, D Greiner, RJ Kaufman, R Bortell, F Urano - Cell metabolism, 2012 - cell.com
Recent clinical and experimental evidence suggests that endoplasmic reticulum (ER) stress
contributes to the life-and-death decisions of β cells during the progression of type 1 and …
contributes to the life-and-death decisions of β cells during the progression of type 1 and …
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones
T Yoneda, C Benedetti, F Urano… - Journal of cell …, 2004 - journals.biologists.com
Protein folding in the mitochondria is assisted by nuclear-encoded compartment-specific
chaperones but regulation of the expression of their encoding genes is poorly understood. We …
chaperones but regulation of the expression of their encoding genes is poorly understood. We …
Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity
…, K Mizuseki, K Watanabe, F Urano… - Proceedings of the …, 2002 - National Acad Sciences
… (F) Suppression of neuronal differentiation by BMP4 and serum. Serum (instead of knockout
… 1F), suggesting that primate and mouse ES cells respond to the same positive (SDIA) and …
… 1F), suggesting that primate and mouse ES cells respond to the same positive (SDIA) and …