Efficiency of recombinant human TNF in human cancer therapy
… The tumours underwent massive haemorrhagic necrosis, hence the name tumour necrosis
factor. The same authors found evidence that the tumour-associated vessels were the prime …
factor. The same authors found evidence that the tumour-associated vessels were the prime …
Clinical applications of TNF-α in cancer
FJ Lejeune, C Rüegg, D Liénard - Current opinion in immunology, 1998 - Elsevier
… extramural re-evaluation of the results using very strict criteria (F LeJeune, unpublished data)
downgraded the rate of complete response rate to 78% and increased the partial response …
downgraded the rate of complete response rate to 78% and increased the partial response …
Regional therapy of melanoma
FJ Lejeune, D Lienard, S Leyvraz… - European Journal of …, 1993 - Elsevier
Little progress has been made in the systemic treatment of melanoma, that is for disseminated
stage IV disease. However, the tumour resistance to therapy, especially chemotherapy …
stage IV disease. However, the tumour resistance to therapy, especially chemotherapy …
High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and …
…, JJ Delmotte, N Renard, FJ Lejeune - Journal of clinical …, 1992 - ascopubs.org
PURPOSE To determine the toxicity and the therapeutic efficacy of the combination of the
recombinant tumor necrosis factor alpha (rTNF alpha), recombinant interferon gamma (rIFN-…
recombinant tumor necrosis factor alpha (rTNF alpha), recombinant interferon gamma (rIFN-…
Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas: the cumulative …
…, C Kettelhack, G Ben-Ari, JC Pector, FJ Lejeune - Annals of …, 1996 - journals.lww.com
Objective The objective of the study was to achieve limb salvage in patients with locally
advanced soft tissue sarcomas that can only be treated by amputation or functionally mutilating …
advanced soft tissue sarcomas that can only be treated by amputation or functionally mutilating …
Evidence for the involvement of endotheliai cell integrin αVβ3 in the disruption of the tumor vascuiature induced by TNF and IFN-γ
…, A Yilmaz, G Bieler, J Bamat, P Chaubert, FJ Lejeune - Nature medicine, 1998 - nature.com
… & Lejeune, FJ High-dose recombinant tumor necrosis factor alpha in combination with …
Lejeune, FJ High dose recombinant tumour necrosis factor (rTNF alpha) administered by …
Lejeune, FJ High dose recombinant tumour necrosis factor (rTNF alpha) administered by …
Isolated limb perfusion with high-dose tumor necrosis factor-alpha in combination with interferon-gamma and melphalan for nonresectable extremity soft tissue …
…, AN van Geel, HJ Hoekstra, FJ Lejeune - Journal of Clinical …, 1996 - ascopubs.org
PURPOSE To determine the efficacy of isolated limb perfusion (ILP) with tumor necrosis
factor-alpha (TNF) in combination with interferon-gamma (IFN) and melphalan as induction …
factor-alpha (TNF) in combination with interferon-gamma (IFN) and melphalan as induction …
Sunscreen use and duration of sun exposure: a double-blind, randomized trial
…, D Lienard, R Panizzon, FJ Lejeune… - Journal of the …, 1999 - academic.oup.com
BACKGROUND: In epidemiologic studies, sunscreen use is associated with increased risk
of cutaneous melanoma, basal cell skin cancer, and higher numbers of nevi. It has been …
of cutaneous melanoma, basal cell skin cancer, and higher numbers of nevi. It has been …
Prophylactic isolated limb perfusion for localized, high-risk limb melanoma: results of a multicenter randomized phase III trial. European Organization for Research and …
…, ET Krementz, D Ruiter, FJ Lejeune - Journal of clinical …, 1998 - ascopubs.org
PURPOSE Patients with primary cutaneous melanoma > or = 1.5 mm in thickness are at high
risk of having regional micrometastases at the time of initial surgical treatment. A phase III …
risk of having regional micrometastases at the time of initial surgical treatment. A phase III …
[HTML][HTML] Microglia-neuron interaction at nodes of Ranvier depends on neuronal activity through potassium release and contributes to remyelination
… E, F Dynamics of microglial tips contacting an internode vs a node in myelinated slices
treated with TEA (D–F, internode: n = 37 contacts from 12 animals, node: n = 10 contacts from 8 …
treated with TEA (D–F, internode: n = 37 contacts from 12 animals, node: n = 10 contacts from 8 …